NCT04942093 (NUTRACOB) is a NA clinical trial of With low-calorie, high-protein diet in Diet, Healthy, sponsored by University Hospital, Rouen.

Who is sponsoring NCT04942093?

NCT04942093 is sponsored by University Hospital, Rouen.

What drugs are being tested in NCT04942093?

Interventions in NCT04942093: With low-calorie, high-protein diet, Without low-calorie, high-protein diet.

What condition does NCT04942093 study?

NCT04942093 studies Diet, Healthy, Obesity, Visceral, Bariatric Surgery Candidate.

Is NCT04942093 still recruiting?

NCT04942093 is currently recruiting now. Last updated 22 September 2025.

Last reviewed 2025-09-22 · How we verify

NCT04942093: NUTRACOB

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

NUTritional Impact of a Hypocaloric Hyperprotein Diet Before Obesity Surgery

Recruiting now NA Last updated 22 September 2025

What this trial tests

NA trial testing With low-calorie, high-protein diet in Diet, Healthy in 200 participants. Currently enrolling.

Timeline

9 October 2023

Primary endpoint
20 November 2026

20 March 2027

Quick facts

Lead sponsor	University Hospital, Rouen
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	supportive care
Enrollment	200
Start date	9 October 2023
Primary completion	20 November 2026
Estimated completion	20 March 2027
Sites	3 locations across France

Drugs / interventions tested

With low-calorie, high-protein diet
Without low-calorie, high-protein diet

Conditions studied

Diet, Healthy — all drugs for Diet, Healthy →
Obesity, Visceral — all drugs for Obesity, Visceral →
Bariatric Surgery Candidate — all drugs for Bariatric Surgery Candidate →

Sponsor

University Hospital, Rouen

Who can join

Adults 18 to 65, any sex, with Diet, Healthy or Obesity, Visceral. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Obesity is a major public health problem and is constantly on the rise. Therapeutic approaches based on dietary advice, physical activity and the management of psychological difficulties are not always sufficient to achieve a lasting weight reduction. Bariatric surgery (or obesity surgery), accompanied by therapeutic education and adequate medical and dietary monitoring, can lead to significant and lasting weight loss. It is indicated as a second-line treatment for patients who have failed medical treatment, whose BMI is greater than or equal to 40 or whose BMI is greater than or equal to 35 with comorbidities (type 2 diabetes, arterial hypertension, obstructive sleep apnoea-hypopnoea syndrome, severe joint disorders). The surgeon may be very bothered by the intra-abdominal fat mass and especially by steatotic hepatomegaly (increase in the size of the liver and its fat load). Faced with this problem, various preoperative strategies such as the placement of an intra gastric balloon have been tried to decrease the size of the liver but a systematic review from 2016 indicates that a low calorie diet is preferable. Preoperative weight loss can reduce fat load and liver volume very rapidly. This meta-analysis shows that all low-calorie, high-protein diets are effective and that the optimal duration (4 weeks), compliance and tolerance are important factors for success.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

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Other University Hospital, Rouen trials

Trials by the same sponsor.

NCT07441564 — Evaluation of the Efficacy of Ischemic Preconditioning to Protect Against Acute Kidney Injury After Open Surgery for Jux · NA · not yet recruiting
NCT07535944 — Prospective Exploration of Vascular Complications Associated With the Use of Immune Checkpoint Inhibitors · not yet recruiting
NCT07464184 — Evolution of Hypoxic Burden and Sympathetic/Parasympathetic Balance in Patients With Pulmonary Hypertension · NA · not yet recruiting
NCT07359885 — Prediction of Postoperative Pulmonary Complications in Thoracic Surgery · not yet recruiting
NCT07247500 — Impact of Reventilation After One-Lung Ventilation in Thoracic Surgery (OLVREEXP) · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04942093 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Rouen
Last refreshed: 22 September 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04942093.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing