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NCT04941430
7T MRI Scan for the Early Detection of Melanoma Brain Metastases
NA trial testing Magnetic Resonance Imaging using 7 Tesla MRI in Clinical Stage IV Cutaneous Melanoma AJCC v8 in 2 participants. Terminated before completion.
10 January 2025
Quick facts
| Lead sponsor | University of Southern California |
|---|---|
| Phase | NA |
| Status | Terminated |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 2 |
| Start date | 25 June 2021 |
| Primary completion | 10 January 2025 |
| Estimated completion | 10 January 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Magnetic Resonance Imaging using 7 Tesla MRI
Conditions studied
- Clinical Stage IV Cutaneous Melanoma AJCC v8 — all drugs for Clinical Stage IV Cutaneous Melanoma AJCC v8 →
- Metastatic Malignant Neoplasm in the Brain — all drugs for Metastatic Malignant Neoplasm in the Brain →
- Metastatic Melanoma — all drugs for Metastatic Melanoma →
- Pathologic Stage IV Cutaneous Melanoma AJCC v8 — all drugs for Pathologic Stage IV Cutaneous Melanoma AJCC v8 →
Sponsor
University of Southern California
Who can join
18 and older, any sex, with Clinical Stage IV Cutaneous Melanoma AJCC v8 or Metastatic Malignant Neoplasm in the Brain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This clinical trial studies the use of 7-Tesla (7T) magnetic resonance imaging (MRI) in detecting melanoma that has spread to the brain (melanoma brain metastases). The standard MRI brain imaging is done on 3T or similar MRI machine, but the 7T MRI machine has a larger magnet which has been shown to have superior resolution of the brain and of non-cancerous brain lesions. Diagnostic procedures such as 7T MRI may help find and diagnose melanoma brain metastases earlier than standard 3T MRI.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Towards updated understanding of brain metastasis.
Wang S, Feng Y, Chen L, Yu J, et al · · 2022 · cited 7× · PMID 36225632
Verify or expand the search:
- PubMed search for NCT04941430
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Clinical Stage IV Cutaneous Melanoma AJCC v8
Currently open trials in the same condition.
- NCT06391099 — Ketogenic Dietary Intervention to Improve Response to Immunotherapy in Patients With Metastatic Melanoma and Metastatic · NA · recruiting
- NCT07155317 — Time-of-Day Specified Immunotherapy for Advanced Melanoma, The TIME Trial · Phase 2 · recruiting
- NCT05896839 — Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metasta · Phase 1, PHASE2 · recruiting
- NCT06265285 — Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access an · Phase 2 · recruiting
- NCT05588453 — Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to · Phase 1, PHASE2 · recruiting
Other University of Southern California trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04941430 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Southern California
- Last refreshed: 12 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04941430.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing