Last reviewed · How we verify
NCT04938661: iCARE
Improving Cardiac Rehabilitation Outcomes Through Mobile Case Management (iCARE)
NA trial testing Center-Based Cardiac Rehab in Acute Myocardial Infarction in 206 participants. Completed in 9 June 2025.
10 April 2025
Quick facts
| Lead sponsor | Mayo Clinic |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 206 |
| Start date | 8 July 2021 |
| Primary completion | 10 April 2025 |
| Estimated completion | 9 June 2025 |
| Sites | 2 locations across United States |
Drugs / interventions tested
- Center-Based Cardiac Rehab
- mHealth
- Home-Based Cardiac Rehab
Conditions studied
- Acute Myocardial Infarction — all drugs for Acute Myocardial Infarction →
- Acute Coronary Syndrome — all drugs for Acute Coronary Syndrome →
- Stable Angina Pectoris — all drugs for Stable Angina Pectoris →
- Percutaneous Coronary Intervention — all drugs for Percutaneous Coronary Intervention →
Sponsor
Mayo Clinic
Who can join
Adults 18 to 80, any sex, with Acute Myocardial Infarction or Acute Coronary Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this research is to find out if doing cardiac rehab at home, or a mix of cardiac rehab at home and in the clinic, is as effective as coming in to the clinic for cardiac rehab.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Home-based versus centre-based cardiac rehabilitation.
McDonagh ST, Dalal H, Moore S, Clark CE, et al · · 2023 · cited 58× · PMID 37888805 · DOI 10.1002/14651858.cd007130.pub5 -
Social network interventions to support cardiac rehabilitation and secondary prevention in the management of people with heart disease.
Purcell C, Dibben G, Hilton Boon M, Matthews L, et al · · 2023 · cited 17× · PMID 37378598 · DOI 10.1002/14651858.cd013820.pub2
Verify or expand the search:
- PubMed search for NCT04938661
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Acute Myocardial Infarction
Currently open trials in the same condition.
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- NCT07536802 — Adenosine Pre-Medication in Primary Percutaneous Coronary Intervention: A Randomized Control Trial · Phase 4 · recruiting
- NCT06947135 — Stellate Ganglion Morphine Infiltration on Myocardial Ischemia-Reperfusion Injury · NA · recruiting
- NCT06515730 — Treatment With Apixaban Versus Warfarin in Patients With Left Ventricular Thrombus After Acute Myocardial Infarction · Phase 4 · recruiting
- NCT07522164 — Acute Myocardial Infarction Clinical Cohort · active not recruiting
Other Mayo Clinic trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04938661 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
- Last refreshed: 20 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04938661.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing