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NCT04931134
Treatment of Anxiety Disorders With Trigeminal Nerve Stimulation
NA trial testing Trigeminal nerve stimulation - active in Panic Disorder in 1 participant. Participants enrolled and being followed up; not accepting new ones.
31 December 2025
Quick facts
| Lead sponsor | Dr. Rafael Freire |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 1 |
| Start date | 7 February 2022 |
| Primary completion | 31 December 2025 |
| Estimated completion | 31 January 2026 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Trigeminal nerve stimulation - active
- Trigeminal nerve stimulation - sham
Conditions studied
- Panic Disorder — all drugs for Panic Disorder →
- Generalized Anxiety Disorder — all drugs for Generalized Anxiety Disorder →
- Social Anxiety Disorder — all drugs for Social Anxiety Disorder →
Sponsor
Dr. Rafael Freire
Who can join
Adults 18 to 65, any sex, with Panic Disorder or Generalized Anxiety Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Primary objectives: The primary objective is to ascertain if trigeminal nerve stimulation is an effective treatment with high tolerability for patients with panic disorder, generalized anxiety disorder and social anxiety disorder.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04931134
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Panic Disorder
Currently open trials in the same condition.
- NCT06661460 — Internet-Delivered Cognitive Behavioral Intervention for Youths With Anxiety Disorders · NA · recruiting
- NCT06934525 — Implementing Team-Based Treatment for Pediatric Anxiety in Community Mental Health Settings · NA · recruiting
- NCT07444879 — IL-33, sST2, and CRP in Panic Disorder · recruiting
- NCT07024758 — Comparative Effectiveness of Internet-based Versus Parent-Coached Cognitive-Behavioral Therapy For Children and Adolesce · NA · recruiting
- NCT06942429 — Stepped Versus Stratified Care for Anxiety Disorders in Youth · NA · recruiting
Other Dr. Rafael Freire trials
Trials by the same sponsor.
- NCT06278909 — Trigeminal Nerve Stimulation in Treatment-resistant Generalized Anxiety Disorder: a Feasibility Study · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04931134 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Dr. Rafael Freire
- Last refreshed: 8 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04931134.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing