NCT04925518

Closed Loop Mechanical Ventilation and ECMO

Completed NA Last updated 14 June 2021

What this trial tests

NA trial testing Closed Loop Mechanical Ventilation in Acute Respiratory Distress Syndrome in 62 participants. Completed in 23 May 2018.

Timeline

6 March 2016

Primary endpoint
23 May 2018

23 May 2018

Quick facts

Lead sponsor	University of Zurich
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	sequential
Masking	none
Primary purpose	treatment
Enrollment	62
Start date	6 March 2016
Primary completion	23 May 2018
Estimated completion	23 May 2018

Drugs / interventions tested

• Closed Loop Mechanical Ventilation
• Conventional Mechanical Ventilation

Conditions studied

• Acute Respiratory Distress Syndrome — all drugs for Acute Respiratory Distress Syndrome →
• Cardiogenic Shock — all drugs for Cardiogenic Shock →

Sponsor

University of Zurich

Who can join

18 and older, any sex, with Acute Respiratory Distress Syndrome or Cardiogenic Shock. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Mechanical ventilation and ECMO are both technologies interacting on gas exchange. Nevertheless, besides a consensus paper, no evidence-based guidelines regarding protective lung ventilation on ECMO exist to date. Mechanical Ventilation with Intellivent-ASV, an algorithm driven, closed loop system, provides an opportunity to standardize ventilation on ECMO.

We propose and validate lung protective ventilation with a closed loop ventilation mode in patients with ECMO.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.