NCT04921449 is a NA clinical trial of ED Physical Therapy in Low Back Pain, sponsored by Northwestern University.

Who is sponsoring NCT04921449?

NCT04921449 is sponsored by Northwestern University.

What drugs are being tested in NCT04921449?

Interventions in NCT04921449: ED Physical Therapy, Usual Care.

What condition does NCT04921449 study?

NCT04921449 studies Low Back Pain.

Is NCT04921449 still recruiting?

NCT04921449 is currently completed. Last updated 14 October 2025.

Last reviewed 2025-10-14 · How we verify

NCT04921449

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

ED Physical Therapy for Acute Low Back Pain

Completed NA Last updated 14 October 2025

What this trial tests

NA trial testing ED Physical Therapy in Low Back Pain in 360 participants. Completed in 25 July 2025.

Timeline

12 July 2021

Primary endpoint
3 October 2024

25 July 2025

Quick facts

Lead sponsor	Northwestern University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	360
Start date	12 July 2021
Primary completion	3 October 2024
Estimated completion	25 July 2025
Sites	1 location across United States

Drugs / interventions tested

ED Physical Therapy
Usual Care

Conditions studied

Low Back Pain — all drugs for Low Back Pain →

Sponsor

Northwestern University

Who can join

18 and older, any sex, with Low Back Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Emergency department (ED)-initiated physical therapy is a rapidly growing resource and represents a promising treatment approach to low back pain. This clinical trial will evaluate an innovative model of an emergency department "embedded" physical therapist to treat patients with acute low back pain, with a focus on improving patient functioning and reducing opioid use.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Embedded emergency department physical therapy versus usual care for acute low back pain: a protocol for the NEED-PT randomised trial.
Kim HS, Muschong KM, Fishman IL, Schauer JM, et al · · 2022 · cited 6× · PMID 35613820 · DOI 10.1136/bmjopen-2022-061283
Application of Algorithm-Based Treatment Approach to Low Back Pain in the Emergency Department.
Strickland KJ, Kim HS, Seitz AL. · · 2025 · PMID 39951510 · DOI 10.1093/ptj/pzaf016

Verify or expand the search:

Other trials of ED Physical Therapy

Trials testing the same drug.

NCT05206630 — ED Physical Therapy for Chronic Low Back Pain · NA · completed

Other recruiting trials for Low Back Pain

Currently open trials in the same condition.

NCT07526012 — Comparative Effects Of Post Isometric Relaxation Versus Active Isolated Stretch In Patients With Piriformis Syndrome · NA · recruiting
NCT07535047 — Placebo-Induced Hypoalgesia During Transcutaneous Electrical Nerve Stimulation Application in Low Back Pain · NA · recruiting
NCT07463729 — Evaluation of Stabilization Training With Biofeedback in Lumbosacral Spine Pain Syndrome · NA · recruiting
NCT07250568 — Office Program Effects on Pain, Posture, Muscle Physiology, Stress, Ergonomics, and Quality of Life in LBP Workers · NA · recruiting
NCT07467070 — Effectiveness of Pilates on Postural Correction, Core Strength and Flexibility in Younger Individuals With Non-specific · NA · recruiting

Other Northwestern University trials

Trials by the same sponsor.

NCT06545695 — Epidermal Growth Factor Receptor Inhibition for Keratinopathies · Phase 1, PHASE2 · not yet recruiting
NCT07261657 — N-803 in Patients With Progressive Synovial Sarcoma and Myxoid/Round Cell Liposarcoma Previously Treated With Adoptive C · EARLY_PHASE1 · not yet recruiting
NCT07392775 — ALDH2 Genetic Testing in East Asian Community · NA · not yet recruiting
NCT06886776 — Implementing A Secure Firearm Storage Program in Illinois Health Centers in Partnership With AllianceChicago and the Ill · NA · not yet recruiting
NCT07469176 — Co-Designing and Evaluating Additional Mothers and Babies Program Content for Expectant and New Parents of Children With · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04921449 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Northwestern University
Last refreshed: 14 October 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04921449.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing