NCT04917406

Effect of Iontophoresis vs. Ultrasound and Iontophoresis in Plantar Fasciitis". Plantar Fasciitis"

Completed NA Last updated 3 July 2023

What this trial tests

NA trial testing Application of lidocaine together with dexamethasone in Iontophoresis in 76 participants. Completed in 1 October 2021.

Timeline

20 May 2021

Primary endpoint
15 September 2021

1 October 2021

Quick facts

Lead sponsor	University of Seville
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	76
Start date	20 May 2021
Primary completion	15 September 2021
Estimated completion	1 October 2021
Sites	1 location across Spain

Drugs / interventions tested

• Application of lidocaine together with dexamethasone — full drug profile →
• Application of ultrasound as physical therapy

Conditions studied

• Iontophoresis — all drugs for Iontophoresis →
• Ultrasound Therapy; Complications — all drugs for Ultrasound Therapy; Complications →
• Fasciitis, Plantar — all drugs for Fasciitis, Plantar →
• Pain, Acute — all drugs for Pain, Acute →

Sponsor

University of Seville

Who can join

Adults 18 to 65, any sex, with Iontophoresis or Ultrasound Therapy; Complications. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Plantar fasciitis is inflammation of plantar fascia.The main symptom of plantar fasciitis manifests itself as localized pain in the inner area of the foot and increases in intensity after long periods of standing or resting. Its etiology is multifactorial and risk factors include overweight, female gender, physical exercise (impact sports), biomechanical imbalances of the foot and possible dysfunction of the functional twin-ankle-plantar system.Generally speaking, conservative measures are recommended as initial treatment for plantar fasciitis, and in situations where these are ineffective, corticosteroids are sometimes administered. At the local level, the route of administration can be by infiltration or iontophoresis.Iontophoresis consists of administering a drug through the skin by applying an electric current locally. This technique can be considered as a safe and effective method within the SLTF (Transcutaneous Drug Delivery Systems). It consists of introducing ions through the skin by means of electricity using a direct current, with an electrode carrying a positive charge (anode) and a negative charge (cathode). Its administration is produced thanks to the repulsive force to carry the compound through the skin by means of galvanic current.

This study aims to assess whether treatment with iontophoresis in subjects with plantar fasciitis can show a more positive evolution in pain after a 6-week treatment period (treatment frequency: 1 time per week) versus ultrasound (3 times per week) for 6 weeks.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Comparison of the Short-Term Effect between Iontophoresis and Radial Extracorporeal Shockwave Therapy in the Treatment of Plantar Fasciitis: A Randomized Controlled Trial.
   Pabón-Carrasco M, Coheña-Jiménez M, Pérez-Belloso AJ, Algaba-Del-Castillo J, et al · · 2024 · cited 2× · PMID 38921337 · DOI 10.3390/healthcare12121223