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NCT04917393: MODUS
Multi-Organ Denervation With the iRF System to RedUce Sympathetic Drive
NA trial testing iRF System Multi-organ Denervation in Hypertension in 45 participants. Status unknown.
1 October 2022
Quick facts
| Lead sponsor | Metavention |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | device feasibility |
| Enrollment | 45 |
| Start date | 13 September 2021 |
| Primary completion | 1 October 2022 |
| Estimated completion | 1 October 2023 |
| Sites | 2 locations across Georgia |
Drugs / interventions tested
- iRF System Multi-organ Denervation
- Control Procedure
Conditions studied
- Hypertension — all drugs for Hypertension →
- Type 2 Diabetes — all drugs for Type 2 Diabetes →
- Metabolic Syndrome — all drugs for Metabolic Syndrome →
Sponsor
Metavention
Who can join
Adults 18 to 80, any sex, with Hypertension or Type 2 Diabetes. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The objective of the study is to evaluate the safety of multi-organ denervation using the Integrated Radio Frequency (iRF) Denervation System. and to understand any potential improvement in hypertension and glycemic control.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Multi-Organ Denervation: The Past, Present and Future.
Haider SA, Sharif R, Sharif F. · · 2025 · cited 2× · PMID 40283576 · DOI 10.3390/jcm14082746
Verify or expand the search:
- PubMed search for NCT04917393
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Hypertension
Currently open trials in the same condition.
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- NCT07238556 — A Novel Digital Tool Physicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors · NA · recruiting
- NCT07238400 — Cardiac Effects of Mineralocorticoid Receptor Antagonism After Preeclampsia · Phase 2 · recruiting
- NCT07135505 — Early Time-Restricted Eating in Older Adults With Hypertension · NA · recruiting
Other Metavention trials
Trials by the same sponsor.
- NCT04740723 — Evaluation of the Integrated Radio Frequency Denervation System for the Treatment of Hypertension · NA · completed
- NCT04285554 — Evaluation of the Integrated Radio Frequency Denervation System to Improve Glycemic Control in Type 2 Diabetic Subjects · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04917393 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Metavention
- Last refreshed: 21 June 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04917393.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing