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NCT04917016
B-HCG Levels in Women Diagnosed With Retained Products of Conception
trial testing Plasma B-HCG levels in Retained Products of Conception in 200 participants. Completed in 28 February 2021.
28 February 2021
Quick facts
| Lead sponsor | Assaf-Harofeh Medical Center |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 200 |
| Start date | 1 December 2019 |
| Primary completion | 28 February 2021 |
| Estimated completion | 28 February 2021 |
| Sites | 1 location across Israel |
Drugs / interventions tested
- Plasma B-HCG levels
Conditions studied
- Retained Products of Conception — all drugs for Retained Products of Conception →
Sponsor
Assaf-Harofeh Medical Center
Who can join
Adults 18 to 45, female only, with Retained Products of Conception. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Retained Products of Conception (RPOC) is a condition where gestational tissue remains in the uterus after birth or after a surgical or medical abortion. This condition may cause significant bleeding, infection, and long-term intrauterine adhesions associated with fertility problems and pregnancy complications (Asherman's syndrome). RPOC are diagnosed according to the clinical and ultrasound findings (such as an echogenic foci in the uterine cavity with Doppler blood flows). However, the diagnosis of RPOC by clinic and ultrasound characteristics is inaccurate and false positive results are reported in up to 40% of women undergoing a surgical procedure for RPOC removal (most often by hysterosocpy). However, surgery also carries a risk of complications and intrauterine infections. Therefore, the need arises for additional tools to improve the diagnosis available today in order to minimize the need for surgical procedures as much as possible. The production and secretion of the B-HCG occurs in the placenta and begins after blastocyst implantation. The B-HCG levels increase in other placental pathologies such as gestational trophoblastic disease (GTD). Accordingly, the investigators hypothesized that in cases of placental remnants a secretion of B-HCG may be detected and quantified. In this prospective, non-interventional study the investigators' aim is to examine whether B-HCG can be used as a marker for detecting placental remnants, compared to the currently accepted sonographic method. For this purpose, the investigators will examine the levels of B-HCG in participants undergoing hysteroscopy for removal of RPOC.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04917016
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Retained Products of Conception
Currently open trials in the same condition.
- NCT07102615 — Intracervical Vasopressin · Phase 4 · recruiting
- NCT07146659 — Comparison of Operative Hysteroscopy Performed in the Operating Room Versus Outpatient Settings · recruiting
- NCT06862089 — A Prospective Study Evaluating the Impact of Conservative Management on Retained Products of Conception and EMV · recruiting
- NCT07421895 — A Prospective Multicenter Observational Real-world Study of Retained Products of Conception · recruiting
- NCT05085067 — The Efficacy of Auto-cross Linked Hyaluronic Acid Gel in the Prevention of Adhesion Reformation After Hysteroscopic Rese · NA · recruiting
Other Assaf-Harofeh Medical Center trials
Trials by the same sponsor.
- NCT07334639 — Metabolic Changes Associated With Weight Gain After Treatment of Achalasia · not yet recruiting
- NCT07276334 — Same Day Discharge Vs. Hospitalization for Operative Fixation of Distal Radius Fractures · NA · enrolling by invitation
- NCT07231900 — Sodium Bicarbonate in Intra-dialytic Hypertension in Chronic Hemodialysis Patients · Phase 2, PHASE3 · not yet recruiting
- NCT07252180 — Comparing Two Different Methods of Ablation of Inlet Patches (APC vs RFA) · NA · active not recruiting
- NCT04664790 — Hyperbaric Oxygen Therapy Compared to Cognitive Training in FASD · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04917016 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Assaf-Harofeh Medical Center
- Last refreshed: 8 June 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04917016.
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