NCT04915365 is a Phase 3 clinical trial of Acetazolamide in Right Heart Function, sponsored by University of Zurich.

Who is sponsoring NCT04915365?

NCT04915365 is sponsored by University of Zurich.

What drugs are being tested in NCT04915365?

Interventions in NCT04915365: Acetazolamide, Placebo.

What condition does NCT04915365 study?

NCT04915365 studies Right Heart Function, Chronic Obstructive Pulmonary Disease, Altitude Sickness.

Is NCT04915365 still recruiting?

NCT04915365 is currently status unknown. Last updated 2 November 2022.

Last reviewed 2022-11-02 · How we verify

NCT04915365

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders With COPD Traveling to High Altitude

Status unknown Phase 3 Last updated 2 November 2022

What this trial tests

Phase 3 trial testing Acetazolamide in Right Heart Function in 100 participants. Status unknown.

Timeline

1 May 2021

Primary endpoint
31 December 2022

31 December 2023

Quick facts

Lead sponsor	University of Zurich
Phase	Phase 3
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	100
Start date	1 May 2021
Primary completion	31 December 2022
Estimated completion	31 December 2023
Sites	1 location across Kyrgyzstan

Drugs / interventions tested

Acetazolamide (ACETAZOLAMIDE) — full drug profile →
Placebo

Conditions studied

Right Heart Function — all drugs for Right Heart Function →
Chronic Obstructive Pulmonary Disease — all drugs for Chronic Obstructive Pulmonary Disease →
Altitude Sickness — all drugs for Altitude Sickness →

Sponsor

University of Zurich

Who can join

Adults 35 to 75, any sex, with Right Heart Function or Chronic Obstructive Pulmonary Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this randomized, placebo-controlled double-blind trial is to evaluate the effect of acetazolamide on right heart function at rest in lowlanders with chronic obstructive pulmonary disease (COPD) traveling to high altitude (HA) and developing early signs of altitude-illness.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Repurposing FDA-approved sulphonamide carbonic anhydrase inhibitors for treatment of <i>Neisseria gonorrhoeae</i>.
Abutaleb NS, Elhassanny AEM, Nocentini A, Hewitt CS, et al · · 2022 · cited 50× · PMID 34894972 · DOI 10.1080/14756366.2021.1991336
Pulmonary haemodynamics by echocardiography over 3 days of acclimatization in lowlanders with chronic obstructive pulmonary disease travelling to 3100 m of high altitude.
Bitos K, Müller J, Omuralieva A, Schneider SR, et al · · 2025 · PMID 40134848 · DOI 10.1093/ehjopen/oeaf017

Verify or expand the search:

Other trials of Acetazolamide

Trials testing the same drug.

NCT07372040 — Add-on Diuretics in Acute Decompensated Heart Failure · Phase 2 · recruiting
NCT06945848 — Venous Stenting Evaluation in Patients With Intracranial Hypertension Under Long-term Acetazolamide · NA · recruiting
NCT07199088 — Comparative Efficacy and Safety of Acetazolamide Versus Metolazone as an Adjunct to Standard Therapy in Patients With Ac · NA · recruiting
NCT03806751 — A Noninvasive Arterial Input Estimation Method for O-15 PET and Integrated PET/MR Scanning · EARLY_PHASE1 · withdrawn
NCT06166654 — Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload · Phase 4 · recruiting

Other University of Zurich trials

Trials by the same sponsor.

NCT07485699 — Soy Processing and Food Allergy · NA · not yet recruiting
NCT07516912 — Evaluation of Free STI Testing Pilot Projects in Lucerne and Zurich, Switzerland · not yet recruiting
NCT07473115 — Individualized Analgesia in the Intensive Care Unit With a New Pain Assessment Bundle and Protocolized Analgesia Adjustm · not yet recruiting
NCT07524023 — Emotional-distress-based Integrated Care Programme in Patients With Stable COPD · NA · recruiting
NCT06481982 — Value of Advanced MRI Techniques in the Assessment of Endometriosis · withdrawn

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04915365 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Zurich
Last refreshed: 2 November 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04915365.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing