NCT04914793: LAMPA

Lao Anti-Microbial Prescribing Guidelines Mobile Phone Application (LAMPA)

Completed NA Last updated 4 October 2023

What this trial tests

NA trial testing Antimicrobial prescribing guideline mobile phone application (MicroGuide) in Infectious Disease in 6 participants. Completed in 31 October 2022.

Timeline

11 January 2021

Primary endpoint
31 October 2022

31 October 2022

Quick facts

Lead sponsor	Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	sequential
Masking	none
Primary purpose	health services research
Enrollment	6
Start date	11 January 2021
Primary completion	31 October 2022
Estimated completion	31 October 2022
Sites	1 location across Laos

Drugs / interventions tested

• Antimicrobial prescribing guideline mobile phone application (MicroGuide)

Conditions studied

• Infectious Disease — all drugs for Infectious Disease →

Sponsor

Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit

Who can join

Eligibility, any sex, with Infectious Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The overall aim of this study is to compare the proportion of antimicrobial prescriptions adherent with prescribing guidelines delivered by mobile phone application (app) versus paper-based prescribing guidelines in both in- and outpatients in six hospitals in Laos.

This is an open cohort stepped-wedge cluster randomized controlled trial 3-step trial (4-month intervals at each step) with a 4-month pre-intervention period). The study conducts in six hospitals across Laos. This is 16 months-study. The intervention is a MicroGuide antimicrobial prescribing guideline mobile phone application and antimicrobial stewardship (AMS) training; whilst the reference is paper-based antimicrobial prescribing guidelines. The main outcome of interest is the proportion of antimicrobial prescriptions adherent with prescribing guidelines delivered by app-based versus paper-based prescribing guidelines at month 16 (12 months' exposure in each group). Outcome measurements are Point prevalence surveys (PPS) of hospital antimicrobial use, prescriber questionnaires and AMS knowledge survey of the prescribers. Simple random sampling will be used to select the order (step) of interventions implementation for a group of hospitals (two hospitals per group and one group per step). Neither hospitals nor investigators are blinded to the timing of intervention. Open Data Kit (ODK) system will be used as data collection instrument. All data will be kept securely, protected by password access with automatic daily backup. A logistic mixed-effects regression model will be used to compare the proportion of antimicrobial prescription adherence measured cross-sectionally at month 0, 4, 8, 12 and month 16 after introduction of prescribing guidelines delivered by mobile phone application versus paper-based. This study was approved by University of Health Sciences, Vientiane, Lao PDR and Oxford Tropical Ethics Committee (OxTREC), University of Oxford, United Kingdom.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Evaluation of trends in hospital antimicrobial use in the Lao PDR using repeated point-prevalence surveys-evidence to improve treatment guideline use.
   Chansamouth V, Chommanam D, Roberts T, Keomany S, et al · · 2022 · cited 11× · PMID 35846979 · DOI 10.1016/j.lanwpc.2022.100531
2. Understanding hospital antimicrobial prescribing decisions and determinants of uptake of new local antimicrobial prescribing guidelines in Laos.
   Chansamouth V, Douangnouvong A, Thammavongsa P, Sombandith X, et al · · 2024 · cited 1× · PMID 39301442 · DOI 10.12688/wellcomeopenres.20884.2