NCT04914468 (HERMES) is a clinical trial in Mitral Valve Disease, sponsored by Universitätsklinikum Hamburg-Eppendorf.

Who is sponsoring NCT04914468?

NCT04914468 is sponsored by Universitätsklinikum Hamburg-Eppendorf.

What condition does NCT04914468 study?

NCT04914468 studies Mitral Valve Disease.

Is NCT04914468 still recruiting?

NCT04914468 is currently recruiting now. Last updated 4 June 2021.

Last reviewed 2021-06-04 · How we verify

NCT04914468: HERMES

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Hamburg TranscathEteR Mitral Valve REplacement RegiStry

Recruiting now Last updated 4 June 2021

What this trial tests

trial in Mitral Valve Disease in 300 participants. Currently enrolling.

Timeline

8 March 2021

Primary endpoint
31 December 2030

31 December 2030

Quick facts

Lead sponsor	Universitätsklinikum Hamburg-Eppendorf
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	300
Start date	8 March 2021
Primary completion	31 December 2030
Estimated completion	31 December 2030
Sites	1 location across Germany

Conditions studied

Mitral Valve Disease — all drugs for Mitral Valve Disease →

Sponsor

Universitätsklinikum Hamburg-Eppendorf — full company profile →

Who can join

Adults 18 to 110, any sex, with Mitral Valve Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The Hamburg TranscathEteR Mitral Valve REplacement RegiStry (HERMES) is a prospective clinical cohort registry aiming to gather follow-up information on short- and long-term outcome of patients with mitral valve disease that undergo transcatheter mitral valve replacement (TMVR) screening. In particular, long-term durability and function of implanted bioprosteses is of utmost interest for both patients and clinicians. Moreover, this study aimes to investigate and compare the different treatment strategies patients undergo after successful or unsuccessful screening for TMVR.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Management of patients with mitral regurgitation ineligible for standard therapy undergoing TMVI screening.
Ludwig S, Sedighian R, Weimann J, Koell B, et al · · 2022 · cited 11× · PMID 34992049 · DOI 10.4244/eij-d-21-00708
Left and Right Ventricular Hemodynamic Response After Transcatheter Mitral Valve Replacement.
Ludwig S, Strotmann LS, Schrage BN, Koell B, et al · · 2024 · cited 2× · PMID 39100583 · DOI 10.1016/j.shj.2024.100322

Verify or expand the search:

Other recruiting trials for Mitral Valve Disease

Currently open trials in the same condition.

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NCT06235385 — European Association of Cardiovascular Imaging Multiple and Mixed Valvular Disease Study · recruiting
NCT04916535 — Prospective Multicenter Study on Mitral Annular Disjunction · NA · active not recruiting
NCT04954404 — Transcatheter Mitral Valve InterventiOn Single Center Registry in CHinese Patients With Mitral Valve Disease (TORCH-M) · NA · recruiting

Other Universitätsklinikum Hamburg-Eppendorf trials

Trials by the same sponsor.

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NCT07009522 — Hamburg Emotion Awareness and Regulation Group Training for Autistic Adolescents (HEART) · EARLY_PHASE1 · not yet recruiting
NCT07115394 — EEG Measurements to Capture DBS-induced Electric Potentials · recruiting
NCT06955884 — Patient Experience of Transoral Versus Transnasal Awake Tracheal Intubation · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04914468 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Universitätsklinikum Hamburg-Eppendorf
Last refreshed: 4 June 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04914468.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing