NCT04910724

Effects of Varying Energy Deficits on Protein Turnover at Rest and Carbohydrate Oxidation During Steady-state Exercise

Completed NA Last updated 21 January 2026

What this trial tests

NA trial testing Energy Deficit in Energy Supply; Deficiency, Severe in 30 participants. Completed in 7 March 2024.

Timeline

16 August 2022

Primary endpoint
7 March 2024

7 March 2024

Quick facts

Lead sponsor	United States Army Research Institute of Environmental Medicine
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	basic science
Enrollment	30
Start date	16 August 2022
Primary completion	7 March 2024
Estimated completion	7 March 2024
Sites	1 location across United States

Drugs / interventions tested

• Energy Deficit

Conditions studied

• Energy Supply; Deficiency, Severe — all drugs for Energy Supply; Deficiency, Severe →
• Energy Supply; Deficiency — all drugs for Energy Supply; Deficiency →
• Stress, Physiological — all drugs for Stress, Physiological →

Sponsor

United States Army Research Institute of Environmental Medicine

Who can join

Adults 18 to 35, any sex, with Energy Supply; Deficiency, Severe or Energy Supply; Deficiency. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This randomized, parallel study will examine the effects of energy balance and varying magnitudes of energy deficit on 1) the protein kinetic responses to consuming high quality protein and 2) carbohydrate oxidation during steady-state exercise. Healthy adults, representative of active duty military personnel, will complete a 2 d energy balance phase followed by a randomly assigned, 5 d energy deficit phase (n=15 per group; 20%, 40% and 60% energy deficit). At the end of each energy phase the effects of energy balance and energy deficit severity on resting postabsorptive (fasting) and postprandial (after consuming \~34 g protein) muscle protein synthesis (MPS) and whole-body protein synthesis, breakdown, and balance (synthesis - breakdown) will be determined. On the next day, the effects energy balance and energy deficit severity on carbohydrate oxidation during steady-state exercise will be determined. Primary study procedures include anthropometric and body composition measures, resting metabolic rate measures, aerobic exercise, tightly controlled diet and exercise interventions, repeated blood sampling, stable isotope infusion, stable isotope ingestion, and percutaneous muscle biopsies. The following hypotheses will be tested: 1) Δ (postprandial - postabsorptive) MPS and Δ whole-body protein balance at rest will progressively decrease as magnitude of energy deficit increases and 2) exogenous carbohydrate oxidation will be higher and endogenous carbohydrate oxidation will be lower during steady-state exercise as magnitude of energy deficit increases.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.