NCT04910074 is a NA clinical trial of Low-level laser therapy in Mandible; Deformity, sponsored by Albert Einstein College of Medicine.

Who is sponsoring NCT04910074?

NCT04910074 is sponsored by Albert Einstein College of Medicine.

What drugs are being tested in NCT04910074?

Interventions in NCT04910074: Low-level laser therapy, Dummy LLLT.

What condition does NCT04910074 study?

NCT04910074 studies Mandible; Deformity, Surgical Healing, Orthognathic Surgery, Nerve Injury.

Is NCT04910074 still recruiting?

NCT04910074 is currently terminated. Last updated 24 June 2025.

Are results published for NCT04910074?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2025-06-24 · How we verify

NCT04910074

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

LLLT Effects on Inferior Alveolar Nerve (IAN) Recovery Post-orthognathic Surgery

Terminated NA Results posted Last updated 24 June 2025

What this trial tests

NA trial testing Low-level laser therapy in Mandible; Deformity in 25 participants. Terminated before completion.

Timeline

1 July 2022

Primary endpoint
23 January 2024

23 January 2024

Quick facts

Lead sponsor	Albert Einstein College of Medicine
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	25
Start date	1 July 2022
Primary completion	23 January 2024
Estimated completion	23 January 2024
Sites	1 location across United States

Drugs / interventions tested

Low-level laser therapy
Dummy LLLT

Conditions studied

Mandible; Deformity — all drugs for Mandible; Deformity →
Surgical Healing — all drugs for Surgical Healing →
Orthognathic Surgery — all drugs for Orthognathic Surgery →
Nerve Injury — all drugs for Nerve Injury →

Sponsor

Albert Einstein College of Medicine

Who can join

15 and older, any sex, with Mandible; Deformity or Surgical Healing. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Inferior Alveolar Nerve Function for Soft Stimuli Primary · 1 week post-surgery

IAN function for soft stimuli was assessed by brushing a cotton swab along a 2cm path of the skin of the mandible and lower lip in 8 regions along the lower jaw. Regions right and left 1, 2 and 3 are on the skin of lower face, 1 cm apart, starting on the midline, and right and left region 4 is the lower lip, separated at the midline. Right and left regions were identified as R1, R2, R3, R4 and L1, L2, L3, and L4, respectively. Patients responded as to whether they were able to feel the cotton swab using a binary Yes (+) or No (-) response. The number of patients who responded Yes is summarized

Group	Value	95% CI
Low-level Therapy Intervention	10
Sham Intervention	3

Group	Value	95% CI
Low-level Therapy Intervention	11
Sham Intervention	8

Group	Value	95% CI
Low-level Therapy Intervention	11
Sham Intervention	6

Group	Value	95% CI
Low-level Therapy Intervention	7
Sham Intervention	2

Group	Value	95% CI
Low-level Therapy Intervention	8
Sham Intervention	1

Group	Value	95% CI
Low-level Therapy Intervention	11
Sham Intervention	8

Group	Value	95% CI
Low-level Therapy Intervention	11
Sham Intervention	8

Group	Value	95% CI
Low-level Therapy Intervention	8
Sham Intervention	2

Inferior Alveolar Nerve Function for Soft Stimuli Primary · 2 weeks post-surgery

Group	Value	95% CI
Low-level Therapy Intervention	8
Sham Intervention	6

Group	Value	95% CI
Low-level Therapy Intervention	9
Sham Intervention	9

Group	Value	95% CI
Low-level Therapy Intervention	10
Sham Intervention	9

Group	Value	95% CI
Low-level Therapy Intervention	7
Sham Intervention	5

Group	Value	95% CI
Low-level Therapy Intervention	7
Sham Intervention	4

Group	Value	95% CI
Low-level Therapy Intervention	10
Sham Intervention	9

Group	Value	95% CI
Low-level Therapy Intervention	10
Sham Intervention	9

Group	Value	95% CI
Low-level Therapy Intervention	6
Sham Intervention	3

Inferior Alveolar Nerve Function for Soft Stimuli Primary · 3 weeks post-surgery

Group	Value	95% CI
Low-level Therapy Intervention	7
Sham Intervention	5

Group	Value	95% CI
Low-level Therapy Intervention	10
Sham Intervention	8

Group	Value	95% CI
Low-level Therapy Intervention	10
Sham Intervention	8

Group	Value	95% CI
Low-level Therapy Intervention	8
Sham Intervention	6

Group	Value	95% CI
Low-level Therapy Intervention	7
Sham Intervention	3

Group	Value	95% CI
Low-level Therapy Intervention	10
Sham Intervention	7

Group	Value	95% CI
Low-level Therapy Intervention	10
Sham Intervention	7

Group	Value	95% CI
Low-level Therapy Intervention	7
Sham Intervention	4

Inferior Alveolar Nerve Function for Soft Stimuli Primary · 4 weeks post-surgery

Group	Value	95% CI
Low-level Therapy Intervention	5
Sham Intervention	6

Group	Value	95% CI
Low-level Therapy Intervention	8
Sham Intervention	9

Group	Value	95% CI
Low-level Therapy Intervention	8
Sham Intervention	9

Group	Value	95% CI
Low-level Therapy Intervention	7
Sham Intervention	7

Group	Value	95% CI
Low-level Therapy Intervention	4
Sham Intervention	6

Group	Value	95% CI
Low-level Therapy Intervention	8
Sham Intervention	9

Group	Value	95% CI
Low-level Therapy Intervention	8
Sham Intervention	9

Group	Value	95% CI
Low-level Therapy Intervention	5
Sham Intervention	5

Inferior Alveolar Nerve Function for Soft Stimuli Primary · 5 weeks post-surgery

Group	Value	95% CI
Low-level Therapy Intervention	6
Sham Intervention	3

Group	Value	95% CI
Low-level Therapy Intervention	6
Sham Intervention	6

Group	Value	95% CI
Low-level Therapy Intervention	6
Sham Intervention	6

Group	Value	95% CI
Low-level Therapy Intervention	6
Sham Intervention	4

Group	Value	95% CI
Low-level Therapy Intervention	3
Sham Intervention	4

Group	Value	95% CI
Low-level Therapy Intervention	6
Sham Intervention	6

Group	Value	95% CI
Low-level Therapy Intervention	6
Sham Intervention	6

Group	Value	95% CI
Low-level Therapy Intervention	3
Sham Intervention	4

Inferior Alveolar Nerve Function for Soft Stimuli Primary · 6 weeks post-surgery

Group	Value	95% CI
Low-level Therapy Intervention	8
Sham Intervention	6

Group	Value	95% CI
Low-level Therapy Intervention	9
Sham Intervention	8

Group	Value	95% CI
Low-level Therapy Intervention	9
Sham Intervention	8

Group	Value	95% CI
Low-level Therapy Intervention	8
Sham Intervention	6

Group	Value	95% CI
Low-level Therapy Intervention	5
Sham Intervention	6

Group	Value	95% CI
Low-level Therapy Intervention	9
Sham Intervention	8

Group	Value	95% CI
Low-level Therapy Intervention	9
Sham Intervention	7

Group	Value	95% CI
Low-level Therapy Intervention	5
Sham Intervention	6

Inferior Alveolar Nerve Function for Soft Stimuli Primary · 8 weeks post-surgery

Group	Value	95% CI
Low-level Therapy Intervention	2
Sham Intervention	4

Group	Value	95% CI
Low-level Therapy Intervention	4
Sham Intervention	5

Group	Value	95% CI
Low-level Therapy Intervention	4
Sham Intervention	5

Group	Value	95% CI
Low-level Therapy Intervention	2
Sham Intervention	4

Group	Value	95% CI
Low-level Therapy Intervention	3
Sham Intervention	3

Group	Value	95% CI
Low-level Therapy Intervention	4
Sham Intervention	5

Group	Value	95% CI
Low-level Therapy Intervention	4
Sham Intervention	5

Group	Value	95% CI
Low-level Therapy Intervention	2
Sham Intervention	4

Inferior Alveolar Nerve Function for Hard Stimuli Primary · 1 week post-surgery

IAN function for hard stimuli was assessed by pressing a toothpick into the skin of the mandible and lower lip in 8 regions along the lower jaw. Regions right and left 1, 2, and 3 are on the skin of the lower face, 1 cm apart, starting on the midline, and right and left region 4 is the lower lip, separated at the midline. Right and left regions were abbreviated as R1, R2, R3, R4 and L1, L2, L3, and L4, respectively. Patients responded as to whether they were able to feel the toothpick using a binary Yes (+) or No (-) response. The number of patients who responded Yes (+) is summarized by study

Group	Value	95% CI
Low-level Therapy Intervention	10
Sham Intervention	2

Group	Value	95% CI
Low-level Therapy Intervention	11
Sham Intervention	8

Group	Value	95% CI
Low-level Therapy Intervention	11
Sham Intervention	8

Group	Value	95% CI
Low-level Therapy Intervention	7
Sham Intervention	2

Group	Value	95% CI
Low-level Therapy Intervention	8
Sham Intervention	0

Group	Value	95% CI
Low-level Therapy Intervention	11
Sham Intervention	6

Group	Value	95% CI
Low-level Therapy Intervention	11
Sham Intervention	8

Group	Value	95% CI
Low-level Therapy Intervention	8
Sham Intervention	4

Inferior Alveolar Nerve Function for Hard Stimuli Primary · 2 weeks post-surgery

Group	Value	95% CI
Low-level Therapy Intervention	6
Sham Intervention	5

Group	Value	95% CI
Low-level Therapy Intervention	10
Sham Intervention	9

Group	Value	95% CI
Low-level Therapy Intervention	10
Sham Intervention	9

Group	Value	95% CI
Low-level Therapy Intervention	7
Sham Intervention	5

Group	Value	95% CI
Low-level Therapy Intervention	6
Sham Intervention	5

Group	Value	95% CI
Low-level Therapy Intervention	10
Sham Intervention	8

Group	Value	95% CI
Low-level Therapy Intervention	10
Sham Intervention	9

Group	Value	95% CI
Low-level Therapy Intervention	5
Sham Intervention	5

Inferior Alveolar Nerve Function for Hard Stimuli Primary · 3 weeks post-surgery

Group	Value	95% CI
Low-level Therapy Intervention	9
Sham Intervention	6

Group	Value	95% CI
Low-level Therapy Intervention	10
Sham Intervention	8

Group	Value	95% CI
Low-level Therapy Intervention	10
Sham Intervention	8

Group	Value	95% CI
Low-level Therapy Intervention	9
Sham Intervention	6

Group	Value	95% CI
Low-level Therapy Intervention	9
Sham Intervention	4

Group	Value	95% CI
Low-level Therapy Intervention	10
Sham Intervention	8

Group	Value	95% CI
Low-level Therapy Intervention	10
Sham Intervention	8

Group	Value	95% CI
Low-level Therapy Intervention	8
Sham Intervention	5

Inferior Alveolar Nerve Function for Hard Stimuli Primary · 4 weeks post-surgery

Group	Value	95% CI
Low-level Therapy Intervention	5
Sham Intervention	7

Group	Value	95% CI
Low-level Therapy Intervention	8
Sham Intervention	9

Group	Value	95% CI
Low-level Therapy Intervention	8
Sham Intervention	9

Group	Value	95% CI
Low-level Therapy Intervention	7
Sham Intervention	8

Group	Value	95% CI
Low-level Therapy Intervention	4
Sham Intervention	6

Group	Value	95% CI
Low-level Therapy Intervention	8
Sham Intervention	9

Group	Value	95% CI
Low-level Therapy Intervention	8
Sham Intervention	9

Group	Value	95% CI
Low-level Therapy Intervention	5
Sham Intervention	5

Inferior Alveolar Nerve Function for Hard Stimuli Primary · 5 weeks post-surgery

Group	Value	95% CI
Low-level Therapy Intervention	6
Sham Intervention	3

Group	Value	95% CI
Low-level Therapy Intervention	6
Sham Intervention	6

Group	Value	95% CI
Low-level Therapy Intervention	6
Sham Intervention	6

Group	Value	95% CI
Low-level Therapy Intervention	5
Sham Intervention	3

Group	Value	95% CI
Low-level Therapy Intervention	3
Sham Intervention	4

Group	Value	95% CI
Low-level Therapy Intervention	6
Sham Intervention	6

Group	Value	95% CI
Low-level Therapy Intervention	6
Sham Intervention	6

Group	Value	95% CI
Low-level Therapy Intervention	3
Sham Intervention	3

Sponsor's own description

Low-level laser therapy (LLLT) is a well-studied technique that has been shown to improve recovery time and reduce pain and swelling in patients undergoing surgery, including orthognathic surgery, and has no known negative effects. This study will use two groups with patients randomly assigned to either the study group, receiving LLLT, or one receiving a placebo treatment, after they have lower jaw surgery. Measurements will be taken at 24 hours, 1 week, 2 week, 3 week, 4 week, 5 week, and 6 week post-op exams to check pain, swelling and nerve function, and the two groups will be compared to see if the LLLT group has any difference

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other trials of Low-level laser therapy

Trials testing the same drug.

NCT07260994 — Comparative Effect of High-Level Versus Low-Level Laser Therapy on Nerve Root Function Among Healthy Young Adults: A Ran · NA · not yet recruiting
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NCT06348849 — The Desensitising Effect of Nanosilver Fluoride in Molar-Incisor Hypomineralisation · Phase 2, PHASE3 · completed
NCT06074120 — Low-level Laser Therapy in Genitourinary Symptoms of Menopause · NA · completed
NCT06220786 — Low Level Laser Therapy for Better Wound Healing · NA · recruiting

Other recruiting trials for Mandible; Deformity

Currently open trials in the same condition.

NCT07245758 — Facial iD Customized Mandible Reconstruction Plates · recruiting

Other Albert Einstein College of Medicine trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04910074 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Albert Einstein College of Medicine
Last refreshed: 24 June 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04910074.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing