NCT04909528 (TREAT-PVC) is a NA clinical trial of Low-level tragus stimulation in Premature Ventricular Contraction, sponsored by The First Affiliated Hospital with Nanjing Medical University.

Who is sponsoring NCT04909528?

NCT04909528 is sponsored by The First Affiliated Hospital with Nanjing Medical University.

What drugs are being tested in NCT04909528?

Interventions in NCT04909528: Low-level tragus stimulation, Sham stimulation.

What condition does NCT04909528 study?

NCT04909528 studies Premature Ventricular Contraction.

Is NCT04909528 still recruiting?

NCT04909528 is currently status unknown. Last updated 11 August 2022.

Last reviewed 2022-08-11 · How we verify

NCT04909528: TREAT-PVC

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

LLTS to Treat Premature Ventricular Contractions

Status unknown NA Last updated 11 August 2022

What this trial tests

NA trial testing Low-level tragus stimulation in Premature Ventricular Contraction in 100 participants. Status unknown.

Timeline

15 March 2021

Primary endpoint
31 December 2022

31 December 2022

Quick facts

Lead sponsor	The First Affiliated Hospital with Nanjing Medical University
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	100
Start date	15 March 2021
Primary completion	31 December 2022
Estimated completion	31 December 2022
Sites	1 location across China

Drugs / interventions tested

Low-level tragus stimulation
Sham stimulation

Conditions studied

Premature Ventricular Contraction — all drugs for Premature Ventricular Contraction →

Sponsor

The First Affiliated Hospital with Nanjing Medical University

Who can join

Adults 18 to 80, any sex, with Premature Ventricular Contraction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This randomized control trial is designed to explore the effect of low-level tragus stimulation in patients with frequent premature ventricular contractions.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Transcutaneous electrical vagus nerve stimulation to suppress premature ventricular complexes (TREAT PVC): study protocol for a multi-center, double-blind, randomized controlled trial.
Cai C, Wu N, Yang G, Yang S, et al · · 2023 · cited 5× · PMID 37872628 · DOI 10.1186/s13063-023-07713-2
Transcutaneous Electrical Vagus Nerve Stimulation to Suppress Ventricular Premature Complexes (TREAT-PVC): A Randomized Clinical Trial.
Wu N, Cai C, Jiang Q, Li C, et al · · 2026 · PMID 42043358 · DOI 10.1016/j.jacep.2026.01.011

Verify or expand the search:

Other trials of Low-level tragus stimulation

Trials testing the same drug.

NCT06802380 — Neuromodulation in Patients With Pulmonary Arterial Hypertension · Phase 1, PHASE2 · not yet recruiting

Other recruiting trials for Premature Ventricular Contraction

Currently open trials in the same condition.

NCT07116525 — A Study Assessing Arrhythmia Mapping With a Multi-Electrode Mapping Catheter · NA · recruiting

Other The First Affiliated Hospital with Nanjing Medical University trials

Trials by the same sponsor.

NCT07377981 — An Exploratory Study of the Efficacy and Safety of Esketamine and Dexmedetomidine in Non-Intubated ICU Patients With Hyp · Phase 4 · not yet recruiting
NCT07523789 — Comparison of Chemotherapy and Immunotherapy in Neoadjuvant Therapy for TNBC · not yet recruiting
NCT07464756 — SHR-1701 With or Without Apatinib in Combination With Chemotherapy as Neoadjuvant Therapy for Gastric Cancer · Phase 2 · not yet recruiting
NCT07482826 — Full-Endoscopic Decompression vs. Endoscopic Lumbar Fusion for Middle-Aged and Older Adults With Spinal Stenosis · NA · not yet recruiting
NCT07558863 — Effect of GLP-1RA on Cardiac Autonomic Neuropathy in Type 2 Diabetes · Phase 4 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04909528 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The First Affiliated Hospital with Nanjing Medical University
Last refreshed: 11 August 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04909528.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing