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NCT04908293
Home Remineralization of White Spot Lesions With Two Different Toothpastes.
NA trial testing Biorepair toothpaste in White Spot Lesion in 40 participants. Completed in 20 October 2021.
15 October 2021
Quick facts
| Lead sponsor | University of Pavia |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 40 |
| Start date | 28 May 2021 |
| Primary completion | 15 October 2021 |
| Estimated completion | 20 October 2021 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Biorepair toothpaste
- Colgate toothpaste
Conditions studied
- White Spot Lesion — all drugs for White Spot Lesion →
Sponsor
University of Pavia
Who can join
Adults 18 to 70, any sex, with White Spot Lesion. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of the study is to compare white spot lesions before, during and after treatment with New Biorepair Advanced Sensitive toothpaste containing micro crystals of hydroxyapatite and Colgate toothpaste with 1450 ppm of fluoride. The timeline will consider the study begin, 15 days, 30 days and 90 days after the beginning of the study. The following indices will be recorded: BEWE Index, Schiff Air Index, VAS scale. After that, patients will fill in a satisfaction questionnaire.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Home Oral Care with Biomimetic Hydroxyapatite vs. Conventional Fluoridated Toothpaste for the Remineralization and Desensitizing of White Spot Lesions: Randomized Clinical Trial.
Butera A, Gallo S, Pascadopoli M, Montasser MA, et al · · 2022 · cited 48× · PMID 35886524 · DOI 10.3390/ijerph19148676
Verify or expand the search:
- PubMed search for NCT04908293
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for White Spot Lesion
Currently open trials in the same condition.
- NCT07319884 — The Role of Fluoride Varnish Application in Preventing White Spot Lesions During Clear Aligner Treatment: A Controlled S · NA · active not recruiting
Other University of Pavia trials
Trials by the same sponsor.
- NCT07491536 — Ozone Therapy With Biomimetic Oral Care for Cancer-Related Oral Mucositis · NA · recruiting
- NCT07421128 — The Pause, Learn, and Activate Yourself (PLAY) · NA · not yet recruiting
- NCT07199712 — Ozone Therapy for Oral Mucositis in Patients Receiving Head and Neck Cancer Radio- and Chemotherapy · NA · completed
- NCT07088653 — Comparison of 0.12% Chlorhexidine and MicroRepair ABX Mouthwash in Gingivitis Management · NA · completed
- NCT07140146 — Trehalose vs Glycine Air-Polishing in Peri-Implant Mucositis Treatment · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04908293 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Pavia
- Last refreshed: 28 October 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04908293.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing