NCT04907110

NR Supplementation and Exercise

Completed NA Last updated 10 February 2023

What this trial tests

NA trial testing Niagen in Overweight and Obesity in 30 participants. Completed in 7 December 2022.

Timeline

10 August 2021

Primary endpoint
2 December 2022

7 December 2022

Quick facts

Lead sponsor	Maastricht University Medical Center
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	prevention
Enrollment	30
Start date	10 August 2021
Primary completion	2 December 2022
Estimated completion	7 December 2022
Sites	1 location across Netherlands

Drugs / interventions tested

• Niagen — full drug profile →
• Exercise

Conditions studied

• Overweight and Obesity — all drugs for Overweight and Obesity →
• Aging — all drugs for Aging →
• Type 2 Diabetes — all drugs for Type 2 Diabetes →

Sponsor

Maastricht University Medical Center

Who can join

Adults 65 to 80, any sex, with Overweight and Obesity or Aging. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The number of age-related chronic diseases (like obesity, type 2 diabetes and cardiovascular diseases) is increasing rapidly worldwide, reaching pandemic proportions. These age-related chronic diseases are associated with metabolic disturbances and mitochondrial dysfunction in humans. Nicotinamide adenosine dinucleotide (NAD) levels play an important role in energy metabolism and mitochondrial functioning and indeed it has been shown that high concentrations of NAD+ as well as a high NAD+/NADH ratio are strongly associated with metabolic and mitochondrial health. In contrast, decreased NAD+ bioavailability is reported in both ageing and obese humans as well as in diabetic mice. These findings fueled the idea of influencing NAD+ bioavailability in order to improve metabolic disturbances and mitochondrial dysfunction in humans. Supplementation with nicotinamide riboside (NR), a naturally occurring form of vitamin B3, may provide a way to boost cellular NAD+ levels. However, in contrast to animal studies, NR supplementation in humans has so far been unsuccessful in improving skeletal muscle mitochondrial function, exercise capacity or insulin sensitivity. Recently, it has been suggested that a situation where NAD+ levels become limited, is needed for NR supplementation to exert beneficial health effects. This situation could be achieved by combining exercise and NR supplementation. However, studies combining NR and exercise are lacking, which is why we would like to perform such a study here.

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

1. Epigenetic regulation of aging: implications for interventions of aging and diseases.
   Wang K, Liu H, Hu Q, Wang L, et al · · 2022 · cited 406× · PMID 36336680 · DOI 10.1038/s41392-022-01211-8
2. Impact of NAD+ metabolism on ovarian aging.
   Liang J, Huang F, Song Z, Tang R, et al · · 2023 · cited 30× · PMID 38041117 · DOI 10.1186/s12979-023-00398-w
3. Chronic HIV Infection and Aging: Application of a Geroscience-Guided Approach.
   Masters MC, Landay AL, Robbins PD, Tchkonia T, et al · · 2022 · cited 21× · PMID 35015744 · DOI 10.1097/qai.0000000000002858
4. Mitophagy-promoting agents and their ability to promote healthy-aging.
   Srivastava V, Gross E. · · 2023 · cited 9× · PMID 37650304 · DOI 10.1042/bst20221363
5. Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications.
   Banerjee P, Olmsted-Davis EA, Deswal A, Nguyen MT, et al · · 2022 · cited 8× · PMID 35801078 · DOI 10.20517/jca.2022.13
6. Development of a <sup>31</sup>P magnetic resonance spectroscopy technique to quantify NADH and NAD<sup>+</sup> at 3 T.
   Mevenkamp J, Bruls YMH, Mancilla R, Grevendonk L, et al · · 2024 · cited 7× · PMID 39443469 · DOI 10.1038/s41467-024-53292-4
7. Epigenetic Regulation of Aging and its Rejuvenation.
   An Y, Wang Q, Gao K, Zhang C, et al · · 2025 · cited 5× · PMID 40904701 · DOI 10.1002/mco2.70369