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NCT04906330

Oncoliq: Test for Early Breast Cancer Detection.

Status unknown Last updated 28 February 2024
What this trial tests

trial testing Oncoliq: test for early breast cancer detection. in Breast Cancer in 500 participants. Status unknown.

Timeline
1 September 2021
Primary endpoint
1 August 2024
1 August 2025

Quick facts

Lead sponsorHospital Militar Central Cirujano Mayor Dr. Cosme Argerich
StatusStatus unknown
Study typeOBSERVATIONAL
Enrollment500
Start date1 September 2021
Primary completion1 August 2024
Estimated completion1 August 2025
Sites1 location across Argentina

Drugs / interventions tested

Conditions studied

Sponsor

Hospital Militar Central Cirujano Mayor Dr. Cosme Argerich

Who can join

Adults 50 to 70, female only, with Breast Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Oncoliq is a novel early breast cancer detection test based on liquid biopsies and microRNAs. This innovative test will allow improving the accuracy of cancer detection which will impact on health, reducing the patient mortality and health costs. To develop this test, it has been finished the preclinical PHASE I: in laboratory animals; PHASE II: exploratory clinical phase for the discovery of candidate biomarkers in breast cancer patients and PHASE III: clinical validation of biomarkers showing that Oncoliq has 91% of sensitivity. Currently it is been setting up a "pilot test" for breast cancer to enrol 500 woman volunteers without previous cancer diagnosis that go to the annual medical control. The results of the pilot test will give the accuracy for early breast cancer detection.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Breast cancer tumor microenvironment affects Treg/IL-17-producing Treg/Th17 cell axis: Molecular and therapeutic perspectives.
    Seif F, Torki Z, Zalpoor H, Habibi M, et al · · 2023 · cited 31× · PMID 36816749 · DOI 10.1016/j.omto.2023.01.001
  2. Addressing the Clinical Feasibility of Adopting Circulating miRNA for Breast Cancer Detection, Monitoring and Management with Artificial Intelligence and Machine Learning Platforms.
    Ling L, Aldoghachi AF, Chong ZX, Ho WY, et al · · 2022 · cited 12× · PMID 36499713 · DOI 10.3390/ijms232315382
  3. Non-Coding RNAs in Breast Cancer: Diagnostic and Therapeutic Implications.
    Beňačka R, Szabóová D, Guľašová Z, Hertelyová Z. · · 2024 · cited 7× · PMID 39795985 · DOI 10.3390/ijms26010127
  4. Potential Impact of Preoperative Circulating Biomarkers on Individual Escalating/de-Escalating Strategies in Early Breast Cancer.
    Gianni C, Palleschi M, Merloni F, Bleve S, et al · · 2022 · cited 4× · PMID 36612091 · DOI 10.3390/cancers15010096
  5. Ambivalent roles of miRNAs in cancer development via modulating tumor-associated innate immune cells.
    Naseri B, Mardi A, Shekari N, Shajari N, et al · · 2025 · PMID 41409584 · DOI 10.34172/bi.31430

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