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NCT04905238
Obstructive Sleep Apnea and Biomarkers of Alzheimer's Disease
NA trial testing Continuous positive airway pressure in Sleep Apnea, Obstructive in 130 participants. Enrolling by invitation.
10 April 2025
Quick facts
| Lead sponsor | Alberto Alonso Fernandez |
|---|---|
| Phase | NA |
| Status | ENROLLING BY INVITATION |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 130 |
| Start date | 31 July 2020 |
| Primary completion | 10 April 2025 |
| Estimated completion | 6 May 2025 |
| Sites | 2 locations across Spain |
Drugs / interventions tested
- Continuous positive airway pressure
Conditions studied
- Sleep Apnea, Obstructive — all drugs for Sleep Apnea, Obstructive →
Sponsor
Alberto Alonso Fernandez
Who can join
Adults 18 to 65, any sex, with Sleep Apnea, Obstructive. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Clinical trial on the effect of continuous positive pressure (CPAP). Objectives: 1) To compare biomarkers of Alzheimer's disease in plasma samples from patients with Obstructive sleep apnea (OSA) and without OSA. 2) To determine if CPAP reduces biomarkers of Alzheimer's disease in plasma samples.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer's disease.
Morrone CD, Raghuraman R, Hussaini SA, Yu WH. · · 2023 · cited 40× · PMID 37085942 · DOI 10.1186/s13024-023-00617-4
Verify or expand the search:
- PubMed search for NCT04905238
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Continuous positive airway pressure
Trials testing the same drug.
- NCT07254026 — Precision Health and Smart Telerehabilitation in OSA · NA · recruiting
- NCT06999746 — Device-Assisted Oropharyngeal Rehabilitation in Obstructive Sleep Apnea Patients Using Continuous Positive Airway Pressu · NA · not yet recruiting
- NCT06463561 — CPAP Effect on Lipid Profile and Hyperuricemia in Patients With Dyslipidemia and Moderate-severe Obstructive Sleep Apnea · Phase 4 · recruiting
- NCT06331819 — Clinical Association Between Obstructive Sleep Apnea, Facial Pigmentation, and Vasovagal Symptoms. · recruiting
- NCT06052514 — CPAP Efficacy in Post-COVID-19 Patients With Sleep Apnea · completed
Other recruiting trials for Sleep Apnea, Obstructive
Currently open trials in the same condition.
- NCT06828835 — The REPOSE (Reach for Equity in Pediatric Sleep Evaluation) Navigation Intervention · NA · recruiting
- NCT06915831 — Type 1 Diabetes and Obstructive Sleep Apnea · NA · recruiting
- NCT07176767 — The IPAD Cohort Study: Insomnia and Positive Airway Pressure Adherence in Children and Adolescents · recruiting
- NCT06573372 — Evaluating the Diagnostic Efficacy of Smartwatch and Smartphone for Sleep Apnea · recruiting
- NCT06848647 — Treatment of Sleep Apnea to Improve Metabolic Health · recruiting
Other Alberto Alonso Fernandez trials
Trials by the same sponsor.
- NCT04444778 — Intermitent Hypoxia and Its Pathophysiology Consequences in the Sleep Apnea-Hypopnea Syndrome. · NA · enrolling by invitation
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04905238 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Alberto Alonso Fernandez
- Last refreshed: 1 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04905238.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing