NCT04901312: POST

Preventing OUD in Justice-Involved Youth

Status unknown NA Last updated 27 October 2022

What this trial tests

NA trial testing Adolescent Community Reinforcement Approach in Substance Use Disorders in 215 participants. Status unknown.

Timeline

20 January 2021

Primary endpoint
31 August 2024

31 August 2024

Quick facts

Lead sponsor	Seattle Children's Hospital
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	sequential
Masking	single
Primary purpose	prevention
Enrollment	215
Start date	20 January 2021
Primary completion	31 August 2024
Estimated completion	31 August 2024
Sites	1 location across United States

Drugs / interventions tested

• Adolescent Community Reinforcement Approach
• Assertive Continuing Care
• Trauma Affect Regulation Guide for Education and Therapy
• Motivational Interviewing
• Opioid Education Workbook

Conditions studied

• Substance Use Disorders — all drugs for Substance Use Disorders →
• Recidivism — all drugs for Recidivism →

Sponsor

Seattle Children's Hospital

Who can join

Adults 15 to 25, any sex, with Substance Use Disorders or Recidivism. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The United States is experiencing an opioid epidemic. Sadly, opioid-related fatalities are on the rise, causing profound emotional, financial, and cultural impacts. One way to reduce these negative impacts is to prevent people from developing opioid use problems in the first place.

Research shows that youth and young adults in the juvenile justice system have higher rates of opioid use disorder than other young people in the general population. The POST Study seeks develop, implement and evaluate the effectiveness and cost of 2 opioid use prevention programs of varying intensities. The prevention programs are designed specifically for youth and young adults living in justice settings. It is implemented during the time they are transitioning out of incarceration and back into the community. The research team hopes their results will help justice settings implement their own effective opioid prevention programs in the future.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Prevention of Opioid Use and Disorder Among Youth Involved in the Legal System: Innovation and Implementation of Four Studies Funded by the NIDA HEAL Initiative.
   Ahrens K, Blackburn N, Aalsma M, Haggerty K, et al · · 2023 · cited 3× · PMID 37393415 · DOI 10.1007/s11121-023-01566-6
2. Investing in Interventions to Prevent Opioid Use Disorder in Adolescents and Young Adults: Start-up Costs from NIDA's HEAL Prevention Initiative.
   Kuklinski MR, Gibbons BJ, Bowser DM, McCollister KE, et al · · 2025 · PMID 41085955 · DOI 10.1007/s11121-025-01835-6
3. Development of the Positive Outcomes through Supported Transition (POST) opioid preventive intervention for youth in the legal system: Study protocol for a sequential multiple assignment randomized trial.
   Brincks AM, Haggerty KP, Kolberg A, Albertson KM, et al · · 2025 · PMID 39706330 · DOI 10.1016/j.cct.2024.107782