NCT04901052

Effects of n-3 Intake on Lipid Profile, Biochemical and Inflammatory Markers in Subjects With Obesity

Completed NA Last updated 15 November 2024

What this trial tests

NA trial testing n-3 supplementation group in Obesity in 58 participants. Completed in 15 March 2019.

Timeline

10 January 2018

Primary endpoint
15 March 2019

15 March 2019

Quick facts

Lead sponsor	University of Guadalajara
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	58
Start date	10 January 2018
Primary completion	15 March 2019
Estimated completion	15 March 2019
Sites	2 locations across Mexico

Drugs / interventions tested

• n-3 supplementation group
• Placebo group

Conditions studied

• Obesity — all drugs for Obesity →

Sponsor

University of Guadalajara

Who can join

Adults 25 to 50, any sex, with Obesity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Obesity is a chronic disease characterized by the excessive accumulation of adipose tissue that is harmful to health. Dietary habits modification through a caloric restriction, macronutrient distribution including linoleic and linolenic (n-6:n-3) polyunsaturated fatty acids (PUFAs) ratio, has been suggested for obesity management. It has been proposed that the optimal n-6: n-3 ratio should be between 1:1 and 5:1 to maintain a healthy balance. Purpose: Compare the effect of a diet n6:n3 ratio of polyunsaturated fatty acids with a group supplemented with n-3 PUFA on lipid profile in erythrocyte membrane, biochemical and inflammatory markers in subjects with obesity.

Methods: 58 subjects were randomly divided into two groups: fish oil group and the placebo group. Anthropometric and biochemical data were evaluated, cytokine levels was performed using the Bio-PlexPro™ HumanTh17Cytokine Assays (MagPix) panel. The fatty acid profile quantification in the erythrocyte membrane was carried out by gas chromatography. Statistical analysis was performed with Statistical Package for the Social Sciences (SPSS) v.22 software.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. A Balanced Dietary Ratio of n-6:n-3 Polyunsaturated Fatty Acids Exerts an Effect on Total Fatty Acid Profile in RBCs and Inflammatory Markers in Subjects with Obesity.
   Gonzalez-Becerra K, Barron-Cabrera E, Muñoz-Valle JF, Torres-Castillo N, et al · · 2023 · cited 35× · PMID 37628530 · DOI 10.3390/healthcare11162333
2. <i>FADS1</i> Genetic Variant and Omega-3 Supplementation Are Associated with Changes in Fatty Acid Composition in Red Blood Cells of Subjects with Obesity.
   Reyes-Pérez SD, González-Becerra K, Barrón-Cabrera E, Muñoz-Valle JF, et al · · 2024 · cited 8× · PMID 39458515 · DOI 10.3390/nu16203522