NCT04900961 (CISCO-21) is a NA clinical trial of Resistance Exercise in Covid19, sponsored by NHS Greater Glasgow and Clyde.

Who is sponsoring NCT04900961?

NCT04900961 is sponsored by NHS Greater Glasgow and Clyde.

What drugs are being tested in NCT04900961?

Interventions in NCT04900961: Resistance Exercise.

Is NCT04900961 still recruiting?

NCT04900961 is currently completed. Last updated 25 February 2025.

Last reviewed 2025-02-25 · How we verify

NCT04900961: CISCO-21

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

CISCO-21 Prevent and Treat Long COVID-19.

Completed NA Last updated 25 February 2025

What this trial tests

NA trial testing Resistance Exercise in Covid19 in 233 participants. Completed in 21 February 2025.

Timeline

1 June 2021

Primary endpoint
30 August 2024

21 February 2025

Quick facts

Lead sponsor	NHS Greater Glasgow and Clyde
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	233
Start date	1 June 2021
Primary completion	30 August 2024
Estimated completion	21 February 2025
Sites	2 locations across United Kingdom

Drugs / interventions tested

Resistance Exercise

Conditions studied

Covid19 — all drugs for Covid19 →

Sponsor

NHS Greater Glasgow and Clyde — full company profile →

Who can join

Eligibility, any sex, with Covid19. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Many people have long-lasting symptoms after COVID-19, such as breathlessness, fatigue and chest pain. So far, research studies of treatments for COVID-19 have focused on the life-threatening acute illness; few studies look at treatments to improve long-term health after COVID-19. COVID-19, particularly when this requires a hospital admission, can lead to weight loss and muscle wasting, contributing to worse outcomes. Muscle strengthening (resistance-based) exercise could improve outcomes in the long-term.

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

Prevention and early treatment of the long-term physical effects of COVID-19 in adults: design of a randomised controlled trial of resistance exercise-CISCO-21.
Morrow A, Gray SR, Bayes HK, Sykes R, et al · · 2022 · cited 15× · PMID 35971155 · DOI 10.1186/s13063-022-06632-y
The effects of long COVID-19, its severity, and the need for immediate attention: Analysis of clinical trials and Twitter data.
Bhattacharyya A, Seth A, Rai S. · · 2022 · cited 4× · PMID 36588926 · DOI 10.3389/fdata.2022.1051386
Post-COVID-19 illness trajectory in community patients: mostly reassuring results.
Berry C, Bayes HK. · · 2022 · cited 2× · PMID 35165717 · DOI 10.1093/eurheartj/ehac057
Resistance Exercise Therapy After COVID-19 Infection: A Randomized Clinical Trial.
Berry C, McKinley G, Bayes HK, Anderson D, et al · · 2025 · cited 1× · PMID 41213124 · DOI 10.1001/jamanetworkopen.2025.34304
Socioeconomic deprivation and illness trajectory in the Scottish population after COVID-19 hospitalization.
Morrow AJ, Sykes R, Saleh M, Zahra B, et al · · 2024 · cited 1× · PMID 38418616 · DOI 10.1038/s43856-024-00455-5
Resistance Exercise Therapy for Long COVID: a Randomized, Controlled Trial
Berry C, McKinley G, Bayes H, Anderson D, et al · · 2025 · DOI 10.21203/rs.3.rs-6269439/v1
The Effects of Long COVID-19, its Severity, and the Need for Immediate Attention: Analysis of Clinical Trials and Twitter data
Bhattacharyya A, Seth A, Rai S. · · 2022 · DOI 10.1101/2022.09.13.22279833

Verify or expand the search:

Other trials of Resistance Exercise

Trials testing the same drug.

NCT07367854 — Diet Synergy in Muscle Protein Synthesis · NA · not yet recruiting
NCT07526909 — Effect of Different Meal Types Given Before Exercise on Plasma Amino Acid Levels and Metabolic Control Parameters in Cla · NA · recruiting
NCT07165106 — Effects of Resistance and Aerobic Exercises on Walking and Sarcopenic Parameters in Parkinson's Disease · NA · completed
NCT06683547 — The Impact of Ketone Monoester Intake on Post-exercise Hormonal Responses After Resistance Exercise in Young Males · NA · completed
NCT07133256 — Effects of Aerobic Versus Resistance Training on Bone Metabolism in Stage 3-4 Chronic Kidney Disease · NA · completed

Other recruiting trials for Covid19

Currently open trials in the same condition.

NCT03305341 — Proof-of-Concept Clinical Pharmacology Trial for COVID-19 Antigen Presentation Therapeutic Biologic Mix · EARLY_PHASE1 · active not recruiting
NCT06482138 — Dysfunction of Olfaction After COVID-19 Infection: Morphological and Histomolecular Investigation · NA · recruiting
NCT04924803 — Community Developed Technology-Based Messaging to Increase COVID-19 Vaccine Uptake Among People Who Inject Drugs · NA · active not recruiting
NCT05013632 — COVID-19 International Drug Pregnancy Registry · recruiting
NCT04806061 — Urine Alkalinisation in COVID-19 · NA · active not recruiting

Other NHS Greater Glasgow and Clyde trials

Trials by the same sponsor.

NCT07403890 — Rewiring the Brain-Immune Axis for Chronic Pain Using Transcranial Magnetic Stimulation in Psoriatic Arthritis · NA · not yet recruiting
NCT07372508 — Glasgow Low-dose CT and AI-based Diagnostics to Case Find Lung Cancer and Other Cardio-respiratory Long-term Conditions · NA · not yet recruiting
NCT07391280 — Strategy for EArly Recognition of Cancer, COPD & Heart Failure in the Emergency Department · NA · not yet recruiting
NCT07048184 — Sarcoma Surgery Wound Complications Comparing Usual Versus Negative Pressure Dressing · Phase 2 · not yet recruiting
NCT06786936 — Evaluating the Role of IL-17 as an Orchestrator of Peripheral-central Cross Talk in Depressive Symptoms · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04900961 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by NHS Greater Glasgow and Clyde
Last refreshed: 25 February 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04900961.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing