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NCT04900714: optiPEEP
Minimizing Lung Injury During Laparoscopy in Steep Trendelenburg Position
NA trial testing Decremental PEEP in Atelectasis in 23 participants. Completed in 23 September 2021.
23 September 2021
Quick facts
| Lead sponsor | University Hospital, Antwerp |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 23 |
| Start date | 21 June 2021 |
| Primary completion | 23 September 2021 |
| Estimated completion | 23 September 2021 |
| Sites | 1 location across Belgium |
Drugs / interventions tested
- Decremental PEEP
- Lung ultrasound score
- Blood gas analysis
- Registration of respiratory mechanics
- Evaluation of dead space
Conditions studied
- Atelectasis — all drugs for Atelectasis →
Sponsor
University Hospital, Antwerp
Who can join
Adults 18 to 80, any sex, with Atelectasis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators hypothesize that the level of PEEP is often suboptimally applied in certain operative conditions, such as in laparoscopy with head down (Trendelenburg) positioning. This can result in excessive levels of lung stress and postoperative pulmonary complications. In patients with steep Trendelenburg and a pneumoperitoneum, the investigators aim to 1. measure apical versus basal atelectasis using the lung ultrasound score 2. compare lung ultrasound scores at different PEEP levels 3. compare respiratory mechanics at the different PEEP levels 4. contrast the optimal PEEP level to standard practice 5. provide guidance to optimal PEEP titration in this setting for the clinician
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Reproducible determination of transpulmonary pressures.
De Meyer GRA, Morrison SG, Saldien V, Jorens PG, et al · · 2022 · PMID 35492208 · DOI 10.1016/j.mex.2022.101696
Verify or expand the search:
- PubMed search for NCT04900714
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Atelectasis
Currently open trials in the same condition.
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Other University Hospital, Antwerp trials
Trials by the same sponsor.
- NCT07455422 — A Study of Barrett's Esophagus Patients: Optimization of a Risk Model to Better Predict the Development of Cancer Recurr · NA · not yet recruiting
- NCT07020715 — A Phase IIa Study of Vitamin D3 Tolerogenic Dendritic Cells (tolDC) for Multiple Sclerosis · Phase 2 · not yet recruiting
- NCT07443761 — Patients Undergoing Pancreatic Surgery at the Antwerp University Hospital. · active not recruiting
- NCT06372847 — DISE-HNS Effect Study · NA · recruiting
- NCT07189091 — CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS · Phase 4 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04900714 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Antwerp
- Last refreshed: 26 January 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04900714.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing