Who is sponsoring NCT04899791?

NCT04899791 is sponsored by Harokopio University.

What drugs are being tested in NCT04899791?

Interventions in NCT04899791: Wheat bread enriched with hydroxytyrosol, Wheat bread.

What condition does NCT04899791 study?

NCT04899791 studies Type 2 Diabetes Mellitus, Obesity.

Is NCT04899791 still recruiting?

NCT04899791 is currently completed. Last updated 2 March 2022.

Last reviewed 2022-03-02 · How we verify

NCT04899791

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Positive Effects of Daily Consumption of Bread Enriched With Hydroxytyrosol on the Results of a 12-week Dietary Intervention on Subjects With Type 2 Diabetes Mellitus and Overweight/ Obesity

Completed NA Last updated 2 March 2022

What this trial tests

NA trial testing Wheat bread enriched with hydroxytyrosol in Type 2 Diabetes Mellitus in 60 participants. Completed in 14 January 2022.

Timeline

24 May 2021

Primary endpoint
24 December 2021

14 January 2022

Quick facts

Lead sponsor	Harokopio University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	60
Start date	24 May 2021
Primary completion	24 December 2021
Estimated completion	14 January 2022
Sites	2 locations across Greece

Drugs / interventions tested

Wheat bread enriched with hydroxytyrosol
Wheat bread

Conditions studied

Type 2 Diabetes Mellitus — all drugs for Type 2 Diabetes Mellitus →
Obesity — all drugs for Obesity →

Sponsor

Harokopio University

Who can join

Adults 18 to 75, any sex, with Type 2 Diabetes Mellitus or Obesity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Hydroxytyrosol is a phenolic compound drawn from the olive tree and its leaves as a by-product obtained from the manufacturing of olive oil and has antioxidant and antidiabetic effects. The use of HT extract in food products is a good strategy to improve their nutritional quality. However, this extract has a strong odour and flavour, so it is important to be encapsulated for the odour and flavour to be covered up. The purpose of the study is to investigate the effects of regular consumption of bread enriched with HT on biochemical parameters (blood glucose and cholesterol levels).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Positive contribution of hydroxytyrosol-enriched wheat bread to HbA<sub>1</sub>c levels, lipid profile, markers of inflammation and body weight in subjects with overweight/obesity and type 2 diabetes mellitus.
Binou P, Stergiou A, Kosta O, Tentolouris N, et al · · 2023 · cited 11× · PMID 37017765 · DOI 10.1007/s00394-023-03133-9

Verify or expand the search:

Other recruiting trials for Type 2 Diabetes Mellitus

Currently open trials in the same condition.

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Other Harokopio University trials

Trials by the same sponsor.

NCT06997510 — Better4All Personalized Intervention · NA · not yet recruiting
NCT07233707 — Load and Hold: Impact of 7-Day Creatine Monohydrate Loading on Breath-Hold Cycling Performance · NA · enrolling by invitation
NCT07505680 — Time-restricted Feeding and Health · NA · completed
NCT07120802 — Better4All Personalized Intervention Pilot Study · NA · recruiting
NCT07190066 — MELIORA Data Collection Campaigns · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04899791 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Harokopio University
Last refreshed: 2 March 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04899791.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing