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NCT04899362

The Impact of Serial Remote Ischemic Conditioning on Dynamic Cerebral Autoregulation in Healthy Adults

Completed NA Results posted Last updated 3 January 2024
What this trial tests

NA trial testing BB-RIC-D1/LAPUL Medical Devices Co, Ltd, China in Remote Ischemic Conditioning in 36 participants. Completed in 30 July 2021.

Timeline
20 May 2021
Primary endpoint
19 July 2021
30 July 2021

Quick facts

Lead sponsorThe First Hospital of Jilin University
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationna
Designsingle group
Maskingnone
Primary purposetreatment
Enrollment36
Start date20 May 2021
Primary completion19 July 2021
Estimated completion30 July 2021
Sites1 location across China

Drugs / interventions tested

Conditions studied

Sponsor

The First Hospital of Jilin University

Who can join

Adults 18 to 50, any sex, with Remote Ischemic Conditioning. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Dynamic Cerebral Autoregulation Parameter: Phase Difference(PD) in Degree Primary · 36 days

Dynamic cerebral autoregulation (dCA) is an important indicator of cerebrovascular function which related to the prognosis of cerebrovascular disease. DCA is usually calculated by transfer function analysis. Phase Difference (PD) is gengreated. Low PD at a low frequency band indicates impairment of autoregulation, as it suggests that cerebral blood flow velocity follows the changes in arterial blood pressure with a short delay.

GroupValue95% CI
RIC Group45.87± 13.02
Dynamic Cerebral Autoregulation Parameter: Gain in cm/s/mmHg Secondary · 36 days

High gain at the same frequency band is also considered an indicator of compromised autoregulation for passively transferring the amplitude of arterial blood pressure to cerebral blood flow velocity.

GroupValue95% CI
RIC Group0.95± 0.25

Sponsor's own description

The purpose of this study is to determine the impact of serial remote ischemic conditioning on dynamic cerebral autoregulation and related hematology indexes in healthy adults.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. The Impact of Serial Remote Ischemic Conditioning on Dynamic Cerebral Autoregulation and Brain Injury Related Biomarkers.
    Qu Y, Zhang P, He QY, Sun YY, et al · · 2022 · cited 12× · PMID 35273521 · DOI 10.3389/fphys.2022.835173

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Other recruiting trials for Remote Ischemic Conditioning

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Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04899362.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing