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NCT04899180
Prevalence of Transthyretin Cardiac Amyloidosis in Clinically Significant Aortic Stenosis
EARLY_PHASE1 trial testing 99mTc-PYP in Aortic Stenosis in 4 participants. Completed in 5 January 2024.
5 January 2024
Quick facts
| Lead sponsor | Mayo Clinic |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 4 |
| Start date | 14 July 2023 |
| Primary completion | 5 January 2024 |
| Estimated completion | 5 January 2024 |
| Sites | 1 location across United States |
Drugs / interventions tested
- 99mTc-PYP — full drug profile →
Conditions studied
- Aortic Stenosis — all drugs for Aortic Stenosis →
- Transthyretin Amyloidosis — all drugs for Transthyretin Amyloidosis →
- Transthyretin Amyloid Cardiomyopathy — all drugs for Transthyretin Amyloid Cardiomyopathy →
- Transthyretin Cardiac Amyloidosis — all drugs for Transthyretin Cardiac Amyloidosis →
Sponsor
Mayo Clinic
Who can join
75 and older, any sex, with Aortic Stenosis or Transthyretin Amyloidosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to determine the prevalence of transthyretin cardiac amyloidosis (TTR-CA) among patients with moderate and severe aortic stenosis in Southeast Minnesota using 99mTc-PYP single-photon positive emission computed tomography with computed tomography (SPECT/CT).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Evaluation of the cardiac amyloidosis clinical pathway implementation: a real-world experience.
Brons M, Muller SA, Rutten FH, van der Meer MG, et al · · 2022 · cited 24× · PMID 35919127 · DOI 10.1093/ehjopen/oeac011
Verify or expand the search:
- PubMed search for NCT04899180
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of 99mTc-PYP
Trials testing the same drug.
- NCT03414632 — Transthyretin Cardiac Amyloidosis in HFpEF · EARLY_PHASE1 · completed
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Currently open trials in the same condition.
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04899180 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
- Last refreshed: 7 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04899180.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing