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NCT04893356: MGMT
Impact of O6-methylguanine-DNA Methyltransferase (MGMT) Promoter Methylation and MGMT Expression on Dacarbazine Treated Sarcoma Patients (MGMT)
trial testing O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and MGMT expression on dacarbazine treated sarcoma patients in Sarcoma in 75 participants. Status unknown.
28 February 2022
Quick facts
| Lead sponsor | National Cancer Institute, Naples |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 75 |
| Start date | 20 January 2021 |
| Primary completion | 28 February 2022 |
| Estimated completion | 20 January 2025 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and MGMT expression on dacarbazine treated sarcoma patients
Conditions studied
- Sarcoma — all drugs for Sarcoma →
Sponsor
National Cancer Institute, Naples
Who can join
Eligibility, any sex, with Sarcoma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
MGMT study is a retrospective, non-profit, multi-center, observational study. The scientific objective of this study is to investigate whether MGMT expression or MGMT promoter methylation may represent a predictive marker for dacarbazine sensitivity in sarcoma patients.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The Impact of O6-Methylguanine-DNA Methyltransferase (<i>MGMT</i>) Promoter Methylation on the Outcomes of Patients with Leiomyosarcoma Treated with Dacarbazine.
Cannella L, Della Monica R, Marretta AL, Iervolino D, et al · · 2023 · cited 4× · PMID 37371106 · DOI 10.3390/cells12121635
Verify or expand the search:
- PubMed search for NCT04893356
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04893356 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National Cancer Institute, Naples
- Last refreshed: 30 October 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04893356.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing