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NCT04889443: SHARC
Spontaneous Healing of ARticular Cartilage (SHARC)
trial testing Surgical cartilage repair procedure requiring harvest procedure or Autologous Stromal Cell Implantation in Cartilage Damage in 15 participants. Completed in 31 December 2023.
31 December 2023
Quick facts
| Lead sponsor | Keele University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 15 |
| Start date | 1 September 2018 |
| Primary completion | 31 December 2023 |
| Estimated completion | 31 December 2023 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Surgical cartilage repair procedure requiring harvest procedure or Autologous Stromal Cell Implantation
Conditions studied
- Cartilage Damage — all drugs for Cartilage Damage →
- Cartilage Injury — all drugs for Cartilage Injury →
Sponsor
Keele University
Who can join
18 and older, any sex, with Cartilage Damage or Cartilage Injury. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
SHARC is an observational study of cartilage patients who are treated with surgery that involves obtaining a harvest biopsy. SHARC will study the natural healing process of the harvest biopsy site based on histological and biochemical analyses of repair tissue biopsies, synovial fluid biomarkers, medical imaging (MRI) and gait analysis.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Advanced Therapy medicinal products for autologous chondrocytes and comparison of regulatory systems in target countries.
Kim J, Park J, Song SY, Kim E. · · 2022 · cited 14× · PMID 35582708 · DOI 10.1016/j.reth.2022.04.004
Verify or expand the search:
- PubMed search for NCT04889443
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Cartilage Damage
Currently open trials in the same condition.
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- NCT04716140 — Prospective Study: The Effect on Clinical Outcome After Treatment of MTP Cartilage Lesions in Hallux Valgus Surgery · NA · recruiting
- NCT03873545 — Prospective Evaluation of ProChondrix CR for Repair of Articular Cartilage Defects on Femoral Condyle and Patella · active not recruiting
Other Keele University trials
Trials by the same sponsor.
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- NCT05842915 — The National Musculoskeletal Audit and Research Database · recruiting
- NCT06049056 — Which Automated Methodology? · completed
- NCT05422937 — Symptom Patterns and Life With Longer Term COVID-19 in Children and Young People (SPLaT-19 Cohort & Qualitative Study) · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04889443 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Keele University
- Last refreshed: 13 March 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04889443.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing