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The GUARDIAN Trial
An international randomized trial to test the primary hypothesis that perioperative tight blood pressure management reduces a composite of major perfusion-related complications (myocardial injury, stroke, non-fatal cardiac arrest, Stage 2-3 acute kidney injury, deep or organ-space infection, sepsis, and death) in the 30 days after major non-cardiac surgery. The treatments will be: 1) norepinephrine or phenylephrine infusion to maintain intraoperative MAP ≥85 mmHg (tight pressure management); or, 2) routine intraoperative blood pressure management (routine pressure management).
Details
| Lead sponsor | The University of Texas Health Science Center, Houston |
|---|---|
| Phase | NA |
| Status | RECRUITING |
| Enrolment | 6254 |
| Start date | Sun Jul 25 2021 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Sun Apr 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Blood Pressure
Interventions
- Tight blood pressure management
- Routine blood pressure management
Countries
Italy, Japan, Greece, China, United States, Turkey (Türkiye)