Who is sponsoring NCT04884022?

NCT04884022 is sponsored by Alexandria University.

What drugs are being tested in NCT04884022?

Interventions in NCT04884022: Miniplates in mandibular symphysis & infrazygomatic, Miniplates in external oblique ridge & anterior maxillary region.

What condition does NCT04884022 study?

NCT04884022 studies Malocclusion.

Is NCT04884022 still recruiting?

NCT04884022 is currently status unknown. Last updated 27 July 2022.

Last reviewed 2022-07-27 · How we verify

NCT04884022

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effectiveness of Two Skeletally Anchored Force Mechanics for Skeletal Class II Correction in Growing Patients

Status unknown NA Last updated 27 July 2022

What this trial tests

NA trial testing Miniplates in mandibular symphysis & infrazygomatic in Malocclusion in 39 participants. Status unknown.

Timeline

8 March 2021

Primary endpoint
1 December 2022

1 December 2022

Quick facts

Lead sponsor	Alexandria University
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	39
Start date	8 March 2021
Primary completion	1 December 2022
Estimated completion	1 December 2022
Sites	1 location across Egypt

Drugs / interventions tested

Miniplates in mandibular symphysis & infrazygomatic
Miniplates in external oblique ridge & anterior maxillary region

Conditions studied

Malocclusion — all drugs for Malocclusion →

Sponsor

Alexandria University

Who can join

Adults 11 to 13, any sex, with Malocclusion. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Patients with skeletal Class II malocclusion due to mandibular retrognathism will be recruited and randomly allocated to three equal groups. first group will be treated by pushing orthopedic force mechanics, second group will be treated by pulling orthopedic force mechanics, and third group will be observed for 9 months to detect the natural growth changes. Skeletal changes will be evaluated and the treatment changes will be compared with the natural growth changes. The study hypothesis is that use of direct bimaxillary miniplate anchorage in conjunction with fixed functional appliance (pushing orthopedic force) or closed coil spring (pulling orthopedic force) will induce statistically significant skeletal mandibular growth in comparison to natural mandibular growth changes.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Comparison between two bone anchored force systems for correction of skeletal Class II malocclusion in growing patients: a randomized controlled clinical trial, part 1: short-term skeletal changes.
Mahmoud YM, Abdel-Haffiez SH, Marzouk ES, El Ashwah AA, et al · · 2025 · cited 1× · PMID 41015417 · DOI 10.2319/111324-934.1
Comparison between two bone anchored force systems for correction of skeletal Class II malocclusion in growing patients: a randomized controlled clinical trial, part 2: short-term dentoalveolar changes.
Mahmoud YM, Marzouk ES, El Ashwah AA, Ismail HA, et al · · 2025 · PMID 41412156 · DOI 10.2319/111324-935.1

Verify or expand the search:

Other recruiting trials for Malocclusion

Currently open trials in the same condition.

NCT05684510 — Treatment of Mild Class II Malocclusion in Adult Patients With Clear Aligners Versus Fixed Multibracket Therapy · NA · recruiting
NCT07290790 — A Prospective Multicenter Clinical Investigation Evaluating the Accuracy of the Trimline Design When Treated With SureSm · NA · recruiting
NCT06858670 — Effectiveness of Auxiliary Segmental Lingual Appliances in Leveling the Curve of Wilson at Second Molars · NA · recruiting
NCT06536335 — Evaluation of the Perceived Experience of Patients Treated With Aligners With Two Different Timings · NA · recruiting
NCT07094581 — Evaluation of the Effect of Adenoid Hypertrophy on the Masseter Muscle in Children: A Comparative Ultrasonographic Study · recruiting

Other Alexandria University trials

Trials by the same sponsor.

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NCT07503626 — Optimization of Orthodontic Bracket Placement by Using Two Different Protocols of Digitally Aided Bonding · NA · recruiting
NCT07522944 — AI-Guided Relaxation for Hemodialysis Anxiety · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04884022 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Alexandria University
Last refreshed: 27 July 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04884022.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing