Who is sponsoring NCT04880148?

NCT04880148 is sponsored by Cyprus University of Technology.

What drugs are being tested in NCT04880148?

Interventions in NCT04880148: Thyme and Honey-based oral spray, Placebo oral spray.

What condition does NCT04880148 study?

NCT04880148 studies Cancer of the Head and Neck, Xerostomia, Oral Mucositis, Radiation Toxicity.

Is NCT04880148 still recruiting?

NCT04880148 is currently status unknown. Last updated 9 December 2021.

Last reviewed 2021-12-09 · How we verify

NCT04880148: HONEY

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effectiveness of a Thyme and Honey Spray for Oral Toxicities

Status unknown NA Last updated 9 December 2021

What this trial tests

NA trial testing Thyme and Honey-based oral spray in Cancer of the Head and Neck in 200 participants. Status unknown.

Timeline

3 November 2021

Primary endpoint
1 June 2024

1 September 2024

Quick facts

Lead sponsor	Cyprus University of Technology
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	supportive care
Enrollment	200
Start date	3 November 2021
Primary completion	1 June 2024
Estimated completion	1 September 2024
Sites	2 locations across Cyprus

Drugs / interventions tested

Thyme and Honey-based oral spray
Placebo oral spray

Conditions studied

Cancer of the Head and Neck — all drugs for Cancer of the Head and Neck →
Xerostomia — all drugs for Xerostomia →
Oral Mucositis — all drugs for Oral Mucositis →
Radiation Toxicity — all drugs for Radiation Toxicity →

Sponsor

Cyprus University of Technology

Who can join

18 and older, any sex, with Cancer of the Head and Neck or Xerostomia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Aim: To evaluate the effectiveness of thymus honey on radiation induced-oral mucositis and xerostomia. Background: Oral mucositis and xerostomia are two of the most severe side effects that head and neck cancer patients confront during and after the completion of radiotherapy. Although several medications are used for their treatment, these fail to provide a fully effective and comprehensive management. Honey and thyme have been studied for the management of various treatment-related side effects. Design: Α double blinded randomised controlled trial will be used for this study. Methods: 200 head and neck cancer patients who receive radiotherapy will be included in this study. Patients will be randomised and divided into two equal groups of 100 participants; the intervention group (oral spray with thyme and honey + standard care) and the control group ( placebo spray + standard care). Assessments with xerostomia and oral mucositis scales additionally to 4 self-administered questionnaires will occur in both groups at baseline and then weekly and 6 months following completion of treatment. The duration of the study will be 3 years from the day of approval of this research protocol.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Salivary toxicity from PSMA-targeted radiopharmaceuticals: What we have learned and where we are going.
Muniz M, Loprinzi CL, Orme JJ, Koch RM, et al · · 2024 · cited 17× · PMID 38703593 · DOI 10.1016/j.ctrv.2024.102748
Cancer treatment-related xerostomia: basics, therapeutics, and future perspectives.
Hosseini MS, Sanaie S, Mahmoodpoor A, Jabbari Beyrami S, et al · · 2024 · cited 12× · PMID 39614391 · DOI 10.1186/s40001-024-02167-x

Verify or expand the search:

Other recruiting trials for Cancer of the Head and Neck

Currently open trials in the same condition.

NCT04470024 — Phase Ib Trial of Multivalent Autophagosome Vaccine With or Without GITR Agonist, With Anti-PD-1 Immunotherapy in HNSCC · Phase 1 · recruiting
NCT02270814 — Cisplatin, Nab-Paclitaxel, and Cetuximab (CACTUX) in Patients With Incurable Head and Neck Squamous Cell Carcinoma · Phase 2 · active not recruiting

Other Cyprus University of Technology trials

Trials by the same sponsor.

NCT06705868 — Chrononutrition/ Chronotoxicity Intervention in People With Metabolic-associated Steatotic Liver Disease. · NA · not yet recruiting
NCT06436131 — The Effects of In-phase Bilateral Exercise in People with Progressive Multiple Sclerosis · NA · completed
NCT05911672 — Testing and Evaluating the Collection of Patient Reported Outcomes In Cancer Care Using Innovative Approaches · NA · unknown
NCT05367947 — In-phase Bilateral Exercises in People With Relapsing Remitting Multiple Sclerosis · NA · completed
NCT04963842 — Investigation on the Benefits of Avoiding Conventional Food Packaging and Promoting Bioplastic Food Packaging · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04880148 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Cyprus University of Technology
Last refreshed: 9 December 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04880148.

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