Last reviewed · How we verify
NCT04875936: ReadingNFB
Neurofeedback Intervention for Reading Deficits in Subacute Stroke
NA trial testing Motor Imagery and Real-Time fMRI Neurofeedback in Stroke in 28 participants. Currently enrolling.
30 June 2026
Quick facts
| Lead sponsor | Kessler Foundation |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 28 |
| Start date | 3 April 2023 |
| Primary completion | 30 June 2026 |
| Estimated completion | 30 June 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Motor Imagery and Real-Time fMRI Neurofeedback
- Motor Imagery and Sham fMRI Neurofeedback
Conditions studied
- Stroke — all drugs for Stroke →
- Dyslexia, Acquired — all drugs for Dyslexia, Acquired →
Sponsor
Kessler Foundation
Who can join
Adults 18 to 80, any sex, with Stroke or Dyslexia, Acquired. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The overall goal of this project is to advance a biologically-based approach to treatment of reading disorders after stroke, which will expand the limits of cognitive rehabilitation. Using a novel brain imaging technique, called real-time functional magnetic resonance imaging (fMRI) neurofeedback combined with right hand motor imagery, this project will re-instate brain activity in the left language-dominant hemisphere. Stroke patients will practice modulating their own brain activity using fMRI neurofeedback signal and will select the most effective mental strategies that help them maintain brain activation patterns associated with better reading recovery.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Feasibility Randomized Controlled Trial of Real-Time fMRI Neurofeedback for Reading Rehabilitation in Aphasia.
Boukrina O, Yamin A, Yue GH, Kong Y, et al · · 2026 · PMID 41958417 · DOI 10.1161/strokeaha.125.054877 -
Feasibility of real-time fMRI neurofeedback for rehabilitation of reading deficits in aphasia
Boukrina O, Yamin A, Yue GH, Kong Y, et al · · 2025 · DOI 10.1101/2025.01.03.25319980
Verify or expand the search:
- PubMed search for NCT04875936
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other Kessler Foundation trials
Trials by the same sponsor.
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- NCT07159100 — tDCS for Cancer-Related Fatigue and Weakness · EARLY_PHASE1 · not yet recruiting
- NCT06886152 — Spinal Stimulation and Gait Training to Improve Mobility in TBI · NA · not yet recruiting
- NCT07073313 — Using Muscle Functional MRI to Study Spatial Muscle Activation Patterns in People With SCI · not yet recruiting
- NCT06923293 — Improving Walking After a Lower Limb Injury Using a Custom Motorized Orthosis · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04875936 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Kessler Foundation
- Last refreshed: 9 October 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04875936.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing