NCT04873531 is a NA clinical trial of Neostigmine in Thyroid Diseases, sponsored by Seoul National University Hospital.

Who is sponsoring NCT04873531?

NCT04873531 is sponsored by Seoul National University Hospital.

What drugs are being tested in NCT04873531?

Interventions in NCT04873531: Neostigmine, Normal saline.

What condition does NCT04873531 study?

NCT04873531 studies Thyroid Diseases, Surgical Injury, Nerve Monitoring.

Is NCT04873531 still recruiting?

NCT04873531 is currently completed. Last updated 4 March 2022.

Last reviewed 2022-03-04 · How we verify

NCT04873531

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Feasibility of Neostigmine for Intraoperative Neuromonitoring in Thyroid Surgery

Completed NA Last updated 4 March 2022

What this trial tests

NA trial testing Neostigmine in Thyroid Diseases in 44 participants. Completed in 31 August 2021.

Timeline

10 May 2021

Primary endpoint
23 August 2021

31 August 2021

Quick facts

Lead sponsor	Seoul National University Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	prevention
Enrollment	44
Start date	10 May 2021
Primary completion	23 August 2021
Estimated completion	31 August 2021
Sites	1 location across South Korea

Drugs / interventions tested

Neostigmine (NEOSTIGMINE) — full drug profile →
Normal saline

Conditions studied

Thyroid Diseases — all drugs for Thyroid Diseases →
Surgical Injury — all drugs for Surgical Injury →
Nerve Monitoring — all drugs for Nerve Monitoring →

Sponsor

Seoul National University Hospital

Who can join

19 and older, any sex, with Thyroid Diseases or Surgical Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

For successful intraoperative neuromonitoring (IONM), adequate reversal of neuromuscular blocking agent is a prerequisite in thyroid surgery with . The aim of this study is to investigate the feasibility of neostigmine just after tracheal intubation on the IONM in thyroid surgery.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Administration of neostigmine after tracheal intubation shortens time to successful intraoperative neuromonitoring during thyroid surgery: a randomized controlled trial.
Oh MY, Chai YJ, Huang TY, Wu CW, et al · · 2022 · cited 3× · PMID 36207389 · DOI 10.1038/s41598-022-21282-5

Verify or expand the search:

Other trials of Neostigmine

Trials testing the same drug.

NCT07524959 — Antagonism of Neostigmine in Continuous Infusion of Mivacurium · NA · not yet recruiting
NCT07309393 — Impact of Sugammadex Versus Neostigmine on Early Postoperative Pulmonary Function · NA · recruiting
NCT07203287 — Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease · Phase 4 · recruiting
NCT06729047 — Prophylactic Intravenous Injection of Neostigmine Plus Atropine Versus Ketorolac on Post-dural Puncture Headache in Pati · Phase 1, PHASE2 · not yet recruiting
NCT06982092 — Using Diaphragm Ultrasonography, Sugammadex Recovers Diaphragmatic Function More Effectively Than Neostigmine. · Phase 1 · completed

Other recruiting trials for Thyroid Diseases

Currently open trials in the same condition.

NCT07462195 — Dexmedetomidine for Improving Emergence Quality in Thyroid Surgery · Phase 4 · recruiting
NCT07382973 — Safety and Efficacy of NTP in Thyroid Surgery: Pilot Study on Morbidity Prevention and Adjuvant Oncological Control · NA · recruiting
NCT07043166 — Cardiovascular-Kidney-Metabolic Syndrome in Shanghai Zicitizens · recruiting
NCT06752239 — Prophylactic Radiotherapy Optimization for Enhanced Thyroid Function Protection in NPC · Phase 3 · recruiting
NCT06730321 — Surgical Competency for Robot-Assisted Thyroidectomy: Construction and Validation of a Robotic Thyroidectomy Assessment · recruiting

Other Seoul National University Hospital trials

Trials by the same sponsor.

NCT07262944 — EOI Block in Otoplasty With Rib Cartilage Graft · NA · recruiting
NCT07464210 — Nemtabrutinib, Bortezomib, and Rituximab for WM · Phase 2 · not yet recruiting
NCT07550803 — Effect of Intraoperative Dexamethasone on Early Postoperative Sleep Quality in Patients Undergoing Nasal Surgery · NA · not yet recruiting
NCT07522138 — Home-based Self-exercise in Patients With Parkinson's Disease: A Feasibility Study · NA · not yet recruiting
NCT07476651 — Scout Dose of Resin Microspheres · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04873531 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Seoul National University Hospital
Last refreshed: 4 March 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04873531.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing