NCT04872374

Effects of Parmigiano Reggiano on Skeletal Muscle Damage in Older Adults

Status unknown NA Last updated 4 May 2021

What this trial tests

NA trial testing Parmigiano Reggiano in Old Age; Atrophy in 20 participants. Status unknown.

Timeline

1 May 2021

Primary endpoint
31 October 2021

1 March 2022

Quick facts

Lead sponsor	University of Padova
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	treatment
Enrollment	20
Start date	1 May 2021
Primary completion	31 October 2021
Estimated completion	1 March 2022
Sites	1 location across Italy

Drugs / interventions tested

• Parmigiano Reggiano
• Whey Protein

Conditions studied

• Old Age; Atrophy — all drugs for Old Age; Atrophy →
• Inflammatory Response — all drugs for Inflammatory Response →
• Muscle Soreness — all drugs for Muscle Soreness →

Sponsor

University of Padova

Who can join

18 and older, any sex, with Old Age; Atrophy or Inflammatory Response. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Aging is associated with the loss of muscle mass and function (sarcopenia) and reduced tissue regenerative capacity.

Eccentric exercise (ECC) is a model of RET that can be used with the elderly, due to the ability of the muscle to combine high muscle strength production with low energy cost. ECC contractions are significantly more damaging to the muscles and produce greater muscle strength, for these reasons there is a greater risk of inducing muscle damage before the muscle is able to adapt.

Parmigiano Reggiano (PR) has some peculiar bromatological characteristics. The proteins contained in it, and in particular the potentially bioactive peptide sequences, can rapidly provide the amino acids necessary to promote muscle growth and repair during exercise. Furthermore, PR can be an important source of fatty acids, of which a significant amount of short-chain fatty acids (SCFA) which are known to have important clinical effects on body composition and metabolic health and can have a systemic anti-inflammatory effect.

Therefore, the central hypothes is that PR consumed during RET can provide more energy substrates and improve muscle recovery. To date, no studies have studied its function on recovery from exercise nor in the elderly.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.