NCT04872088

Integrated Research on Acute Malnutrition in Mali (IRAM-MALI)

Completed NA Last updated 28 October 2022

What this trial tests

NA trial testing Strengthened SBCC in Acute Malnutrition in Childhood in 9,797 participants. Completed in 15 October 2022.

Timeline

6 May 2021

Primary endpoint
15 July 2022

15 October 2022

Quick facts

Lead sponsor	International Food Policy Research Institute
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	other
Enrollment	9,797
Start date	6 May 2021
Primary completion	15 July 2022
Estimated completion	15 October 2022
Sites	1 location across Mali

Drugs / interventions tested

• Strengthened SBCC
• Preventive nutritional supplement
• Family MUAC
• Active screening by NASGs
• Intensified followup of children with wasting referred to and enrolled in CMAM treatment
• Relapse prevention
• Cooking demonstrations

Conditions studied

• Acute Malnutrition in Childhood — all drugs for Acute Malnutrition in Childhood →
• Wasting — all drugs for Wasting →

Sponsor

International Food Policy Research Institute

Who can join

Adults 6 Months to 23 Months, any sex, with Acute Malnutrition in Childhood or Wasting. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The IRAM MALI impact evaluation uses a cluster-randomized controlled study design to assess the impact of the package of integrated interventions aimed at reducing the longitudinal prevalence of wasting by reducing the incidence of child wasting, enhancing the recovery/cure rate from wasting treatment and reducing the relapse rate determined three months after post-treatment recovery from wasting. These interventions include, among other things, strengthening of community care groups (NASGs); home visits with delivery of behavioral change communication about nutrition, health and hygiene (WASH) for young children; distribution of a preventive nutritional supplement; and improved coverage of wasting screening (family MUAC and community screening), management, adherence to treatment and prevention of relapse in the health district of Koutiala, Sikasso region, Mali, West Africa.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. The impact of a continuum of care intervention from prevention to treatment on child wasting compared with usual community group activities: a cluster-randomized controlled trial in Mali.
   Huybregts L, Diop L, Fall T, Barba FM, et al · · 2026 · PMID 41895698 · DOI 10.1016/j.ajcnut.2026.101294