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NCT04871633

Effectiveness of Remedesvir in COVID-19 Patients Presenting at Mayo Hospital Lahore

Completed NA Last updated 4 May 2021
What this trial tests

NA trial testing Remdesivir in COVID-19 in 66 participants. Completed in 30 December 2020.

Timeline
1 August 2020
Primary endpoint
15 November 2020
30 December 2020

Quick facts

Lead sponsorKing Edward Medical University
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingnone
Primary purposetreatment
Enrollment66
Start date1 August 2020
Primary completion15 November 2020
Estimated completion30 December 2020
Sites1 location across Pakistan

Drugs / interventions tested

Conditions studied

Sponsor

King Edward Medical University

Who can join

12 and older, any sex, with COVID-19. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Currently, several drugs including Remdesivir, hydroxychloroquine, chloroquine, ritonavir+lopinavir, Tocilizumab, Arbidol and interferon are under randomised controlled trials (RCTs) for efficacy and/or safety evaluations in patients with COVID-19 in different countries. Remdesivir (GS-5734) is among these investigational drugs and some studies reported promising results. Remdesivir is a nucleotide analogue intravenous pro-drug developed by Gilead Sciences, an American biopharmaceutical company, for treatment of Ebola virus during the 2014 Ebola outbreak in Western Africa. Remdesivir shows broad-spectrum antiviral activity against many RNA viruses including SARS-CoV-2 through blocking RNA polymerase thereby terminating RNA transcription. Remdesivir was among the first treatments used in China as the outbreak emerges and it has been reported as potential treatment options for COVID-19 in the USA, China and Italy.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Prospective Medicinal Plants and Their Phytochemicals Shielding Autoimmune and Cancer Patients Against the SARS-CoV-2 Pandemic: A Special Focus on Matcha.
    Kiriacos CJ, Khedr MR, Tadros M, Youness RA. · · 2022 · cited 5× · PMID 35664773 · DOI 10.3389/fonc.2022.837408

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Other trials of Remdesivir

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Data sources for this page

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