NCT04867122 is a NA clinical trial of Problem-Solving Therapy in Depression, Anxiety, sponsored by Washington University School of Medicine.

Who is sponsoring NCT04867122?

NCT04867122 is sponsored by Washington University School of Medicine.

What drugs are being tested in NCT04867122?

Interventions in NCT04867122: Problem-Solving Therapy, Attention-matched Control, In-depth interviews.

What condition does NCT04867122 study?

NCT04867122 studies Depression, Anxiety, Palliative Care, Caregivers, Cancer.

Is NCT04867122 still recruiting?

NCT04867122 is currently completed. Last updated 8 January 2026.

Last reviewed 2026-01-08 · How we verify

NCT04867122

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Problem-Solving Therapy for Cancer Caregivers in Outpatient Palliative Care

Completed NA Last updated 8 January 2026

What this trial tests

NA trial testing Problem-Solving Therapy in Depression, Anxiety in 532 participants. Completed in 1 December 2025.

Timeline

24 January 2022

Primary endpoint
1 December 2025

1 December 2025

Quick facts

Lead sponsor	Washington University School of Medicine
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	supportive care
Enrollment	532
Start date	24 January 2022
Primary completion	1 December 2025
Estimated completion	1 December 2025
Sites	3 locations across United States

Drugs / interventions tested

Problem-Solving Therapy
Attention-matched Control
In-depth interviews

Conditions studied

Depression, Anxiety — all drugs for Depression, Anxiety →
Palliative Care — all drugs for Palliative Care →
Caregivers — all drugs for Caregivers →
Cancer — all drugs for Cancer →

Sponsor

Washington University School of Medicine

Who can join

18 and older, any sex, with Depression, Anxiety or Palliative Care. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is a randomized clinical trial of a problem-solving therapy intervention for family caregivers of individuals with cancer receiving outpatient palliative care.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

Loneliness, psychological distress, and the moderating effect of positive aspects of caregiving among cancer caregivers.
Jabbari J, Pitzer KA, White Makinde K, Benson JJ, et al · · 2024 · cited 6× · PMID 38833189 · DOI 10.1007/s00520-024-08599-9
Defining Family-Centered Cancer Care: A Group Concept Mapping Study.
Washington KT, Rolbiecki AJ, Becker TD, Makinde KW, et al · · 2025 · cited 3× · PMID 40671195 · DOI 10.1002/pon.70235
Does Family Functioning Matter? Understanding the Relationship Between Family Interactions and Depressive Symptoms for Caregivers of Cancer Patients.
White Makinde K, Pitzer KA, Benson JJ, Mitchell M, et al · · 2025 · cited 2× · PMID 38881044 · DOI 10.1177/10499091241263016
Exploring associations between area deprivation index, income, and loneliness among cancer caregivers.
Pitzer K, Jabbari J, Demiris G, Sedhom R, et al · · 2026 · cited 1× · PMID 41851399 · DOI 10.1007/s00520-026-10578-1
Emotional ecosystems: Understanding the relationship between family interactions and anxiety among cancer caregivers.
Makinde KW, Benson JJ, Pitzer KA, Mitchell M, et al · · 2025 · cited 1× · PMID 39881581 · DOI 10.1017/s147895152400213x
Relationship between problem solving dimensions and psychological distress among cancer caregivers.
Stolker S, Pitzer KA, Koplitz C, Demiris G, et al · · 2025 · PMID 40079692 · DOI 10.1080/07347332.2025.2476142

Verify or expand the search:

Other recruiting trials for Depression, Anxiety

Currently open trials in the same condition.

NCT07278466 — The COMParing App Support Strategies Study · NA · recruiting
NCT07280481 — Weekly Dynamics of Psychopathological and Symptom Networks During Mindfulness-Based Interventions for Emotional Distress · NA · recruiting
NCT07014852 — Integrating Inuit Knowledge Principles in Multi-Level Mental Health Clinical Trials · EARLY_PHASE1 · recruiting
NCT07186816 — SUpport From PEeRs to Expand Access Study - Community · NA · recruiting
NCT07091032 — Building Connections · NA · recruiting

Other Washington University School of Medicine trials

Trials by the same sponsor.

NCT05521997 — Glutaminase Inhibition and Chemoradiation in Advanced Cervical Cancer · Phase 2 · not yet recruiting
NCT07101666 — Total Neoadjuvant Therapy With Short Course Radiation Therapy in Gastric Cancer · Phase 2 · not yet recruiting
NCT07200089 — Recombinant Human IL-7 (NT-I7) in Relapsed/Refractory Multiple Myeloma Following BCMA CAR-T Therapy (Cilta-cel) · Phase 1 · not yet recruiting
NCT07313592 — Whole Genome Sequencing (ChromoSeq®) for Acute Lymphoblastic Leukemia (ALL) Patients · not yet recruiting
NCT07419464 — 5-Fluorouracil Response and Optimization STudy (The FROST Trial) · Phase 2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04867122 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Washington University School of Medicine
Last refreshed: 8 January 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04867122.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing