Adults 18 to 59, any sex, with Sexually Transmitted Diseases. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Rectal Doxycycline ConcentrationPrimary· 24 hours after a single dose
Doxycycline concentration in tissue from a rectal biopsy was measured. Rectal biopsies were obtained from men. Women had the option to provide a rectal tissue sample.
Group
Value
95% CI
Doxycycline and Biktarvy
0.654
0.305 – 1.237
Vaginal Doxycycline ConcentrationPrimary· 24 hours after a single dose
Doxycycline concentration in tissue from a vaginal biopsy was measured.
Group
Value
95% CI
Doxycycline and Biktarvy
0.367
0.203 – 1.445
Plasma Doxycycline ConcentrationPrimary· 24 hours after a single dose
Doxycycline concentration in plasma was measured.
Group
Value
95% CI
Doxycycline and Biktarvy
487
305 – 824
Rectal Bictegravir ConcentrationSecondary· 24 hours after a single dose
Bectegravir concentration in tissue from a rectal biopsy was measured.
Group
Value
95% CI
Doxycycline and Biktarvy
0.085
NA – 0.391
Vaginal Bictegravir ConcentrationSecondary· 24 hours after a single dose
Bictegravir concentration in tissue from a vaginal biopsy was measured.
Group
Value
95% CI
Doxycycline and Biktarvy
0.207
NA – 1.038
Sponsor's own description
The study will determine tissue pharmacology of a single dose of doxycycline for sexually transmitted infection (STI) Post-exposure Prophylaxis (PEP).
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
NCT07306234 — Doxycycline vs. Macrolide for MRMP (DOMINO)
· Phase 4
· not yet recruiting
NCT07230028 — Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study.
· Phase 4
· not yet recruiting
NCT07343635 — The Efficacy and Safety of Anti-inflammation Treatment (Hirudoid Introduction Followed by Yellow Light Therapy) Combined
· NA
· recruiting
NCT07164131 — Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lacta
· Phase 4
· recruiting
NCT06915688 — A Study Comparing Doxycycline and Levofloxacin for Treating COPD Exacerbations
· NA
· not yet recruiting
Other recruiting trials for Sexually Transmitted Diseases
Currently open trials in the same condition.
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· recruiting
NCT05910580 — Improving Alcohol and Substance Use Care Access, Outcome, Equity During the Reproductive Years
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· recruiting
NCT06503666 — Zambian Informed Motivated Aware Responsible Adolescent Girls and Adults
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· recruiting
NCT06579781 — Evaluation of Parent Toolkit 2.0 (Morehouse Family Health Study)
· NA
· recruiting
NCT05977491 — Point-of-care Tests for Vaginal Discharge in Nepal
· NA
· active not recruiting
Other Emory University trials
Trials by the same sponsor.
NCT06143345 — HIIT in Isolated IFG: A Proof-of-Concept Study
· NA
· withdrawn
NCT07189819 — Innovative Closed-loop Functional Electrical Stimulation Control System for Augmenting Post-stroke Gait
· NA
· not yet recruiting
NCT06451055 — Low-calorie Diet in Isolated Impaired Fasting Glucose
· NA
· not yet recruiting
NCT07405476 — Zanidatamab Before Surgery for the Treatment of HER2 Positive Colon and Rectal Cancer in Patients Planned for Curative I
· Phase 2
· recruiting
NCT06708351 — Enhancing Cervical Cancer Screening and Treatment in Women Living With HIV in Kenya, the ENHANCE LINKAge Trial
· NA
· not yet recruiting
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Emory University
Last refreshed: 23 May 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04860505.