Last reviewed · How we verify
NCT04856215: RITII
90Y-labelled Anti-CD66 ab in Childhood High Risk Leukaemia
Phase 2 trial testing 90-Yttrium-labelled anti-CD66 monoclonal antibody in Leukemia in 25 participants. Status unknown.
30 September 2025
Quick facts
| Lead sponsor | Great Ormond Street Hospital for Children NHS Foundation Trust |
|---|---|
| Phase | Phase 2 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 25 |
| Start date | 29 September 2023 |
| Primary completion | 30 September 2025 |
| Estimated completion | 30 September 2025 |
| Sites | 2 locations across United Kingdom |
Drugs / interventions tested
- 90-Yttrium-labelled anti-CD66 monoclonal antibody — full drug profile →
Conditions studied
- Leukemia — all drugs for Leukemia →
Sponsor
Great Ormond Street Hospital for Children NHS Foundation Trust
Who can join
Adults 6 Months to 18, any sex, with Leukemia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Children affected by high risk or relapsed/refractory leukaemia have a poor prognosis, with an increased risk of relapse. These patients generally need treatment intensification and a bone marrow transplantation (BMT). Nevertheless, with conventional treatent the risk of relapse after transplant remains high. Radioimmunotherapy provides a way to deliver high dose irradiation to the bone marrow (where leukaemia resides), while sparing normal organs and tissues from its toxicity.This can be achieved by linking a radioactive molecule (Yttrium90) to an antibody that, once infused in the blood, targets marrow/leukemic cells.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Radioimmunotherapy in Oncology: Overview of the Last Decade Clinical Trials.
Rondon A, Rouanet J, Degoul F. · · 2021 · cited 40× · PMID 34771732 · DOI 10.3390/cancers13215570
Verify or expand the search:
- PubMed search for NCT04856215
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Great Ormond Street Hospital for Children NHS Foundation Trust trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04856215 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Great Ormond Street Hospital for Children NHS Foundation Trust
- Last refreshed: 3 October 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04856215.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing