NCT04849923

Validation of a Digital Twin Performing Strength Training

Status unknown NA Last updated 12 July 2022

What this trial tests

NA trial testing Strength training session in Healthy in 36 participants. Status unknown.

Timeline

1 January 2022

Primary endpoint
31 December 2023

31 July 2024

Quick facts

Lead sponsor	Swiss Federal Institute of Sport Magglingen
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	other
Enrollment	36
Start date	1 January 2022
Primary completion	31 December 2023
Estimated completion	31 July 2024
Sites	1 location across Switzerland

Drugs / interventions tested

• Strength training session

Conditions studied

• Healthy — all drugs for Healthy →

Sponsor

Swiss Federal Institute of Sport Magglingen

Who can join

Adults 20 to 40, any sex, with Healthy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background: Muscular strength training interventions have long been a cornerstone in the prevention, non-surgical management and rehabilitation of the entire spectrum of musculoskeletal injuries and diseases. The key goal of strength training, especially during rehabilitation, is to regain healthy musculoskeletal function. Yet, there remains a fundamental lack of understanding with regards to the relationship between subject-specific musculoskeletal biomechanics (i.e. multi-body dynamics function) and different types of strength training interventions because of limitations in assessing these parameters outside the research setting. Thus, clinicians, physiotherapists and coaches continue making training recommendations based on subjective and generalised guidelines, with ineffective or possibly harmful consequences for individual patients and athletes.

Goal: This project aims to advance strength training guidelines and monitoring of training safety and efficiency by means of subject-specific anatomically-based modelling, biomechanical analysis of musculoskeletal function and mobile monitoring of training volume and muscular fatigue in the athletic and recreational setting.

Method: For validation purposes, the investigators will conduct an 8-week intervention study in healthy volunteers with three levels of strength training volume of the key muscle-tendon groups associated with knee joint stability and relate the changes in musculoskeletal and biomechanical parameters to the training-specific parameters and muscular fatigue from mobile monitoring through correlation analysis.

Relevance: In Switzerland, more than 1.3 Mio people are members of a fitness center. Strength training is not only a cornerstone in the maintenance of fitness and rehabilitation from musculoskeletal injuries and diseases as the most frequently reported health issues.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. The Potential Use of Digital Twin Technology for Advancing CAR-T Cell Therapy.
   Aghamiri SS, Amin R. · · 2025 · cited 4× · PMID 40699720 · DOI 10.3390/cimb47050321