NCT04848896 (CORI RCT TKA) is a NA clinical trial of CORI Robotics in Arthroplasty, sponsored by Smith & Nephew, Inc..

Who is sponsoring NCT04848896?

NCT04848896 is sponsored by Smith & Nephew, Inc..

What drugs are being tested in NCT04848896?

Interventions in NCT04848896: CORI Robotics, Conventional Procedure.

What condition does NCT04848896 study?

NCT04848896 studies Arthroplasty, Replacement, Knee.

Is NCT04848896 still recruiting?

NCT04848896 is currently recruiting now. Last updated 11 March 2026.

Last reviewed 2026-03-11 · How we verify

NCT04848896: CORI RCT TKA

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Study to Evaluate the Safety and Effectiveness of the REAL INTELLIGENCE™ CORI™ in Total Knee Arthroplasty (TKA) Procedure

Recruiting now NA Last updated 11 March 2026

What this trial tests

NA trial testing CORI Robotics in Arthroplasty in 140 participants. Currently enrolling.

Timeline

12 February 2022

Primary endpoint
17 April 2026

31 March 2028

Quick facts

Lead sponsor	Smith & Nephew, Inc.
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	140
Start date	12 February 2022
Primary completion	17 April 2026
Estimated completion	31 March 2028
Sites	4 locations across China, Hong Kong, New Zealand, Australia

Drugs / interventions tested

CORI Robotics
Conventional Procedure

Conditions studied

Arthroplasty — all drugs for Arthroplasty →
Replacement — all drugs for Replacement →
Knee — all drugs for Knee →

Sponsor

Smith & Nephew, Inc. — full company profile →

Who can join

18 and older, any sex, with Arthroplasty or Replacement. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background: REAL INTELLIGENCE™ CORI™ (CORI Robotics) is a computer-assisted orthopaedic surgical navigation and burring system. CORI Robotics is designed to help surgeons in planning and executing certain types of knee surgery involving bone preparation. These types of surgery are called 'unicondylar knee arthroplasty' (UKA) and 'total knee arthroplasty' (TKA). Purpose: This study is being carried out to demonstrate the safety and effectiveness of the CORI Robotics in TKA procedure. The data collected will be used to demonstrate the safety and effectiveness of CORI and to register CORI in China mainland. The primary objective of this study is to evaluate the use of CORI in TKA procedure in achieving post-operative leg alignment as compared to procedures using conventional manual instruments. Research participants / locations: 140 research participants will be recruited from up to 8 sites in 3 countries globally (Australia, China Mainland, Hong Kong and New Zealand). There will be 70 patients having TKA using CORI and 70 patients having TKA using conventional procedure.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other trials of CORI Robotics

Trials testing the same drug.

NCT04786119 — Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in Knee Arthroplasty Procedures · NA · completed

Other recruiting trials for Arthroplasty

Currently open trials in the same condition.

NCT07425457 — Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial) · NA · recruiting
NCT06323980 — INHANCE Stemless Reverse Shoulder IDE · NA · recruiting
NCT04849884 — To Evaluate the Performance of the CORI™ KNEE TENSIONER as an Accessory to the CORI™ Surgical System. · NA · active not recruiting
NCT05190666 — Healthy Living After Knee Replacement · NA · active not recruiting

Other Smith & Nephew, Inc. trials

Trials by the same sponsor.

NCT07025304 — Post-Market Clinical Study to Evaluate the Safety and Effectiveness of REFLEX ULTRA 45 for Coblation Inferior Turbinate · NA · recruiting
NCT06916728 — A Post Approval Multicenter 10 Year Follow-up Observational Trial of Marketed Product - MP01 vs. Surgical Standard of Ca · enrolling by invitation
NCT06831448 — Human Participant Study of a Prototype Multilayer Foam Dressing on Intact Skin. · NA · completed
NCT06700850 — Human Participant Study of Prototype Non-medicated Multilayer Foam Dressings on Intact Skin · NA · completed
NCT06306716 — A Clinical Study on New Negative Pressure Wound Therapy Dressing in the Management of Chronic & Acute Wounds · terminated

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04848896 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Smith & Nephew, Inc.
Last refreshed: 11 March 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04848896.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing