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NCT04847999

Dark Chocolate and Glucose Levels in Diabetes

Completed NA Results posted Last updated 27 February 2025
What this trial tests

NA trial testing Dark chocolate in Type 2 Diabetes in 14 participants. Completed in 4 May 2021.

Timeline
20 November 2020
Primary endpoint
4 May 2021
4 May 2021

Quick facts

Lead sponsorUniversity of British Columbia
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationrandomized
Designcrossover
Maskingtriple
Primary purposeprevention
Enrollment14
Start date20 November 2020
Primary completion4 May 2021
Estimated completion4 May 2021
Sites1 location across Canada

Drugs / interventions tested

Conditions studied

Sponsor

University of British Columbia

Who can join

Adults 18 to 75, any sex, with Type 2 Diabetes or Type 1 Diabetes. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Blood Glucose Incremental Area Under the Curve Primary · 0 and 120 min after consumption of chocolate bar

A self-monitoring blood glucose device (OneTouch Verio IQ® kit Blood glucose monitoring system) will be used to measure blood glucose levels before and after consumption of chocolates. Incremental area under the curve will calculate the glucose above baseline fasting values across 120 minutes.

GroupValue95% CI
Dark Chocolate240.5± 55.81
Ross Dark Chocolate83.81± 46.18
Peak Blood Glucose Concentration Secondary · 0 and 120 minutes after consumption of chocolate bar

Highest blood glucose value measured after consumption of the chocolate bar

GroupValue95% CI
Ross Dark Chocolate10.6± 2.9
Conventional Dark Chocolate11.9± 4.1
Peak Blood Glucose Concentration Above Baseline Secondary · Throughout study completion: 0-120 minutes after consumption of chocolate bar

Highest blood glucose value above fasting baseline after consumption of the chocolate bar

GroupValue95% CI
Ross Dark Chocolate2.2± 2.2
Conventional Dark Chocolate3.5± 2.9
Blood Glucose Secondary · 0 and 120 minutes

A self-monitoring blood glucose device (OneTouch Verio IQ® kit Blood glucose monitoring system) will be used to measure blood glucose levels before and after consumption of chocolates. Total area under the curve will calculate the glucose above zero across 120 minutes.

GroupValue95% CI
Ross Dark Chocolate1090.8± 257.7
Conventional Dark Chocolate1247.5± 390.1
Taste Questionnaire - 0 to 100 Point Scale Secondary · Throughout study completion:120 min after consumption of chocolate bar

Self-reported taste of chocolate bars will be assessed by questionnaire with ratings from awful (0), average (50) to fantastic (100).

GroupValue95% CI
Ross Dark Chocolate51.6± 22
Conventional Dark Chocolate66± 18.5

Sponsor's own description

Diabetes is a growing concern in the world with an estimated 9.3% of adults, ages 20-79, with it in 2019, type 2 diabetes accounting for 90% of this total. A common recommendation for individuals with diabetes is to limit sugars and sweets as it may cause a high blood glucose response. As a result, chocolate is often avoided due to the sugar content; though, high-polyphenol chocolate may have a beneficial effect on hyperglycaemia and vascular function. The sugar-free chocolate from Ross Chocolates is formulated with a blend of inulin, erythritol, and stevia. These alternatives to sugar are not expected to cause a significant change in blood glucose levels following consumption. The main objective of this study is to verify glucose levels before and after consumption of Ross Chocolates' blend of sweeteners dark chocolate and conventional chocolate in people with diabetes.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

  1. The Role of Nutraceutical Containing Polyphenols in Diabetes Prevention.
    Fernandes I, Oliveira J, Pinho A, Carvalho E. · · 2022 · cited 18× · PMID 35208257 · DOI 10.3390/metabo12020184
  2. Sugar-Free Dark Chocolate Consumption Results in Lower Blood Glucose in Adults With Diabetes.
    Oliveira B, Falkenhain K, Little JP. · · 2022 · cited 4× · PMID 35153489 · DOI 10.1177/11786388221076962

Verify or expand the search:

Other trials of Dark chocolate

Trials testing the same drug.

Other recruiting trials for Type 2 Diabetes

Currently open trials in the same condition.

Other University of British Columbia trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04847999.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing