NCT04844229

Bilateral Sphenopalatine Ganglion Block With or Without Bilateral Greater Occipital Nerve Block for Treatment of Obstetric Post-Dural Puncture Headache

Completed NA Last updated 18 October 2022

What this trial tests

NA trial testing Bilateral transnasal sphenopalatine ganglion block. in Post-Dural Puncture Headache in 42 participants. Completed in 30 June 2022.

Timeline

20 June 2021

Primary endpoint
30 May 2022

30 June 2022

Quick facts

Lead sponsor	Zagazig University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	42
Start date	20 June 2021
Primary completion	30 May 2022
Estimated completion	30 June 2022
Sites	1 location across Egypt

Drugs / interventions tested

• Bilateral transnasal sphenopalatine ganglion block.
• Bilateral ultrasound guided greater occipital nerve block.

Conditions studied

• Post-Dural Puncture Headache — all drugs for Post-Dural Puncture Headache →

Sponsor

Zagazig University

Who can join

Adults 21 to 40, female only, with Post-Dural Puncture Headache. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Post-dural puncture headache is a common complication, following neuraxial techniques. The obstetric population is particularly prone to PDPH. Therefore, treatment of PDPH is a key issue in obstetric anesthesia. Conservative treatment for PDPH includes adequate hydration, systemic analgesia with paracetamol and non-steroidal anti-inflammatory drugs and increased caffeine intake, as well as bed rest. If these measures are unsuccessful, the gold standard for the treatment of PDPH is the epidural blood patch which is an invasive technique.

The use of nerve blocks for treating headache symptoms are well known techniques that have been previously used for managing some specific types of chronic headache such as cervicogenic headache, cluster headache, migraine, and occipital neuralgia and there are some recently published studies reporting that these blocks may be beneficial in treating PDPH and the available evidence although showing improvements in the visual analogue (VAS) scores and a reduced number of patients requiring an epidural blood patch, but it is still poor.

Less invasive techniques such as SPG block and GONB are attractive therapeutic options which may eliminate the need for EBP in obstetric patients suffering from PDPH. Up to the best of our knowledge this is the first randomized trial to investigate the analgesic efficacy of adding SPG block either alone or in combination with GONB to PDPH treatment.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.