NCT04842773: MESSAGE

Ultrasound (US) Measurement of Sarcopenia in the Elder Subject

Completed NA Last updated 15 November 2023

What this trial tests

NA trial testing Ultrasound measurement in Sarcopenia in 200 participants. Completed in 31 August 2023.

Timeline

26 October 2021

Primary endpoint
31 August 2023

31 August 2023

Quick facts

Lead sponsor	Centre Hospitalier Universitaire de Nice
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	diagnostic
Enrollment	200
Start date	26 October 2021
Primary completion	31 August 2023
Estimated completion	31 August 2023
Sites	1 location across France

Drugs / interventions tested

• Ultrasound measurement

Conditions studied

• Sarcopenia — all drugs for Sarcopenia →

Sponsor

Centre Hospitalier Universitaire de Nice

Who can join

75 and older, any sex, with Sarcopenia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Sarcopenia is a generalized, progressive and multifactorial muscle impairment, causing multiple pathologies and their consequences such as falls, fractures, dependence, worsening of cognitive disorders and death. Interventions to combat the progression of sarcopenia should be introduced as soon as clinically suspected, based on functional tests to measure muscle strength. Diagnostic confirmation of sarcopenia can be done using several validated methods of estimating muscle mass: magnetic resonance imaging (MRI), computed tomography (CT), biphotonic absorptiometry (DEXA) or bio-impedanceometry. Their availability in clinical routine remains limited due to their high costs and/or lack of accessibility depending on the place of practice. On the other hand, there are certain pitfalls for carrying out these various examinations, in connection with several common clinical problems in the study population: mobility disorders and neurodegenerative disorders disabling for transport and access to the examination table for imaging examinations, hydration disorders distorting measures for bio-impedancetry.

Previous studies suggest that ultrasound may be as effective a tool as previous methods for diagnostic confirmation of sarcopenia. Because of its non-invasive and non-irradiating nature, its affordability, its short duration of realization, its availability and its low constraints of realization, the ultrasound could help to remove some of the current limits to the diagnostic confirmation of sarcopenia.

The investigators hypothesis is that ultrasound can be used to implement a simple and reliable protocol for assessing sarcopenia in the elderly. It could also be used to detect sarcopenia at an early stage ("presarcopenia") while the decrease in muscle mass is not yet accompanied by a decrease in skeletal muscle strength.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Ultrasonographic Measurement of Severe Sarcopenia in the Elderly Subject.
   Michel E, Sarrazy V, Chorin F, Raffaelli C, et al · · 2025 · PMID 40130743 · DOI 10.1097/phm.0000000000002743