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NCT04841759
The Effects of a Multi-factorial Rehabilitation Program for Healthcare Workers Suffering From Post-COVID-19 Fatigue Syndrome
NA trial testing Exercise in COVID-19 in 46 participants. Completed in 22 December 2021.
3 December 2021
Quick facts
| Lead sponsor | Medical University of Vienna |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | supportive care |
| Enrollment | 46 |
| Start date | 1 April 2021 |
| Primary completion | 3 December 2021 |
| Estimated completion | 22 December 2021 |
| Sites | 1 location across Austria |
Drugs / interventions tested
- Exercise
Conditions studied
- COVID-19 — all drugs for COVID-19 →
Sponsor
Medical University of Vienna
Who can join
Adults 18 to 65, any sex, with COVID-19. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The SARS-CoV2 pandemic has kept the world in suspense for over a year now. Almost 100 million people around the world have contracted COVID-19 to date and over 2 million people have died of COVID-19 by the end of January 2021. Despite the tragedy of these deaths, it must be pointed out at this point that the number of COVID-19 survivors is significantly larger. These COVID-19 survivors are now the focus of interest in rehabilitation measures, as it has been shown that survival of the disease does not go hand in hand with a complete cure. Thirty-five percent of all COVID-19 survivors and 87% of the COVID-19 survivors who were hospitalized in the course of their illness suffer from after-effects that are currently summarized as post-COVID fatigue syndrome also known as "Long-COVID". As health care workers are at higher risk of contracting SARS CoV2 and furthermore, considering their central role in the overcoming of this pandemic, a COVID-19 rehabilitation program for healthcare workers of the Medical University of Vienna, Austria as well as the General Hospital of Vienna, Austria - together the second-largest university-clinic in the world - was developed as part of workplace health promotion. Nowadays, the fatigue syndrome is primarily known as a side effect of cancer treatment and thus from the rehabilitation of cancer patients. Cancer-related fatigue is a massive limiting side effect for patients and the currently most effective treatment strategy against cancer-associated fatigue syndrome is physical training. The idea for this current project is, that physical exercise might have similar effects on post-SARS-CoV2 fatigue as it has on cancer-related fatigue. The current study evaluates the effects of this primarily exercise-based rehabilitation program on Long-COVID fatigue.
Publications & conference data
5 peer-reviewed publications reference this trial (live from Europe PMC):
-
Registered clinical trials investigating treatment of long COVID: a scoping review and recommendations for research.
Ceban F, Leber A, Jawad MY, Yu M, et al · · 2022 · cited 52× · PMID 35282780 · DOI 10.1080/23744235.2022.2043560 -
Exercise program for the management of anxiety and depression in adults and elderly subjects: Is it applicable to patients with post-covid-19 condition? A systematic review and meta-analysis.
Piva T, Masotti S, Raisi A, Zerbini V, et al · · 2023 · cited 22× · PMID 36634854 · DOI 10.1016/j.jad.2022.12.155 -
At a crossroads: coronavirus disease 2019 recovery and the risk of pulmonary vascular disease.
Cascino TM, Desai AA, Kanthi Y. · · 2021 · cited 10× · PMID 34127622 · DOI 10.1097/mcp.0000000000000792 -
Long COVID Symptom Management Through Self-Care and Nonprescription Treatment Options: A Narrative Review.
Kachroo P, Boivin G, Cowling BJ, Shannon W, et al · · 2025 · PMID 41007506 · DOI 10.3390/ijerph22091362 -
Facilitators and barriers of long-term exercise adherence in healthcare workers formerly suffering from post-COVID-19 syndrome : A qualitative 1-year follow-up and quantitative pilot study of the COFIT trial.
Hasenöhrl T, Scharer B, Steiner M, Schmeckenbecher J, et al · · 2024 · PMID 39367278 · DOI 10.1007/s00508-024-02446-x
Verify or expand the search:
- PubMed search for NCT04841759
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04841759 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Medical University of Vienna
- Last refreshed: 27 December 2021
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