NCT04841460

Impact of Beef's Unique Food Matrix on Human Health

Completed NA Last updated 12 April 2021

What this trial tests

NA trial testing Low-fat ground beef in Cholesterol, LDL in 25 participants. Completed in 30 September 2019.

Timeline

18 February 2019

Primary endpoint
19 July 2019

30 September 2019

Quick facts

Lead sponsor	Texas A&M University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	triple
Primary purpose	basic science
Enrollment	25
Start date	18 February 2019
Primary completion	19 July 2019
Estimated completion	30 September 2019
Sites	1 location across United States

Drugs / interventions tested

• Low-fat ground beef
• High-fat ground beef

Conditions studied

• Cholesterol, LDL — all drugs for Cholesterol, LDL →
• Cholesterol, HDL — all drugs for Cholesterol, HDL →
• Research Subjects — all drugs for Research Subjects →

Sponsor

Texas A&M University

Who can join

Eligibility, male only, with Cholesterol, LDL or Cholesterol, HDL. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The primary goal of the proposed research is to document changes in plasma lipoprotein fractions, including high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particle sizes and functionality, following the ground beef interventions. This specifically addresses the hypothesis that increasing the amount of fat in ground beef reduces risk factors for cardiovascular disease. Also, the investigators will measure changes in glucose, insulin, and triacylglycerols (TAG) following low-fat and high-fat ground beef interventions. An important aspect of this research is that the investigators will confirm that consumption of high-fat ground beef will reduce carbohydrate intake and increase insulin sensitivity in men. Furthermore, the investigators will be able to establish which protein sources are voluntarily replaced by the low- and high-fat ground beefs.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Consuming High-Fat and Low-Fat Ground Beef Depresses High-Density and Low-Density Lipoprotein Cholesterol Concentrations, and Reduces Small, Dense Low-Density Lipoprotein Particle Abundance.
   Lytle JR, Price T, Crouse SF, Smith DR, et al · · 2023 · cited 4× · PMID 36678207 · DOI 10.3390/nu15020337
2. Assessment of Vascular Function in Response to High-Fat and Low-Fat Ground Beef Consumption in Men.
   Lytle JR, Stanelle ST, Martin SE, Smith SB, et al · · 2023 · cited 2× · PMID 36986140 · DOI 10.3390/nu15061410
3. High unprocessed beef intake (>100 g/d) linked to elevated triglyceride levels: evidence from cross-sectional and Mendelian randomization in Chinese and American adult populations.
   Yi Z, Ding S, Liu X, Liu S, et al · · 2026 · PMID 42221767 · DOI 10.3389/fnut.2026.1790394