NCT04837495

Stellate Ganglion Block in Control of Arrhythmia in Laparoscopic Cholecystectomy

Completed NA Last updated 5 December 2023

What this trial tests

NA trial testing right stellate ganglion block in Arrythmia in 40 participants. Completed in 31 July 2022.

Timeline

30 April 2021

Primary endpoint
25 July 2022

31 July 2022

Quick facts

Lead sponsor	Assiut University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	40
Start date	30 April 2021
Primary completion	25 July 2022
Estimated completion	31 July 2022
Sites	1 location across Egypt

Drugs / interventions tested

• right stellate ganglion block

Conditions studied

• Arrythmia — all drugs for Arrythmia →
• Pain, Acute — all drugs for Pain, Acute →

Sponsor

Assiut University

Who can join

Adults 20 to 60, any sex, with Arrythmia or Pain, Acute. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

During Laparoscopic cholecystectomy, carbon dioxide (CO2) pneumoperitoneal laparoscopic surgery, CO2-pneumoperitoneum activates the sympathoadrenomedullary system to increase the release of catecholamines such as epinephrine (E) norepinephrine (NE) and dopamine (DA). During stress, E and NE are secreted by the adrenal medulla into blood circulation to promote glycogenolysis to increase blood glucose, speed up lipolysis and accelerate heartbeats. Stellate g anglion block (SGB) reters to the blockade of sympathetic nerves including the large area covered by middle cervical, vertebral arterial. stellate ganglions and ther pre- and post- ganglions. SGB affects both peripheral and central nervous systems. In the peripheral system. the sympathetic pre- and post-ganglionic fibers in the innervated areas of stellate ganglion are affected. Therefore, the control of vascular dilatation and constriction, muscular movement, bronchial smooth muscle relaxation and contraction, and pain conduction, by sympathetic nerves is inhibited. In the central nervous system, the hypothalamus is mainly involved in the regulation of systemic autonomic nervous, immune and endocrine systems, and to maintain homeostasis.

CO2-pneumoperitoneum causes severe stress-related homeostatic disorders including arrhythmia and blood pressure changes. This study will examine the effects of stellate ganglion block (SGB) on hemodynamics and stress response in patients undergoing CO-pneumoperitoneal surgery.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Neuromodulatory Approaches for Atrial Fibrillation Ablation.
   Rodríguez-Mañero M, Martínez-Sande JL, García-Seara J, González-Ferrero T, et al · · 2021 · cited 1× · PMID 35024055 · DOI 10.15420/ecr.2021.05