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NCT04837391: POCD
Postoperative Cognitive Dysfunction in Elderly Urologic Oncology Patients (POCD)
trial testing Near Infrared Spectroscopy (NIRS) in Postoperative Cognitive Dysfunction in 48 participants. Status unknown.
21 May 2021
Quick facts
| Lead sponsor | Istanbul University |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 48 |
| Start date | 21 April 2020 |
| Primary completion | 21 May 2021 |
| Estimated completion | 21 July 2021 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Near Infrared Spectroscopy (NIRS)
- Blood sample — full drug profile →
- Addenbrooke Cognitive Examination III (ACE-III)
- Confusion Assessment Method
Conditions studied
- Postoperative Cognitive Dysfunction — all drugs for Postoperative Cognitive Dysfunction →
- Postoperative Delirium — all drugs for Postoperative Delirium →
- Frailty — all drugs for Frailty →
Sponsor
Istanbul University
Who can join
65 and older, any sex, with Postoperative Cognitive Dysfunction or Postoperative Delirium. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Postoperative cognitive changes are more common in elderly patients, which can result in poor quality of life, loss of workforce, disability, early retirement, physical-social dependence, increased health care cost and premature mortality. Postoperative cognitive complications are also quite common in extensive oncological surgeries. In this study, our aim is to evaluate the relationship between the development of postoperative cognitive dysfunction (POCD) in geriatric urologic oncology patients with brain injury and inflammatory markers \[S100 β, neuron specific enolase (NSE), interleukin 6 (IL-6) and high mobility group box-1 (HMGB-1 protein)\].
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Immunogenic Cell Death, DAMPs and Prothymosin α as a Putative Anticancer Immune Response Biomarker.
Birmpilis AI, Paschalis A, Mourkakis A, Christodoulou P, et al · · 2022 · cited 66× · PMID 35563721 · DOI 10.3390/cells11091415 -
The relation between postoperative cognitive disorders and brain damage biomarkers after major urologic surgery: a prospective cohort study.
Şentürk E, Sungur Z, Şentürk Çiftçi H, Kıkılı Mİ, et al · · 2025 · PMID 41345719 · DOI 10.1186/s13741-025-00597-7
Verify or expand the search:
- PubMed search for NCT04837391
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Currently open trials in the same condition.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04837391 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Istanbul University
- Last refreshed: 8 April 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04837391.
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