NCT04834245

Evaluation of Diabetic Foot Wound Healing Using Hydrogel/Nano Silver-based Dressing vs. Traditional Dressing

Completed NA Last updated 8 April 2021

What this trial tests

NA trial testing Hydrogel/nano silver-based dressing in Diabetes Mellitus in 30 participants. Completed in 30 December 2019.

Timeline

3 January 2019

Primary endpoint
3 April 2019

30 December 2019

Quick facts

Lead sponsor	Magda Bayoumi
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	supportive care
Enrollment	30
Start date	3 January 2019
Primary completion	3 April 2019
Estimated completion	30 December 2019
Sites	1 location across Egypt

Drugs / interventions tested

• Hydrogel/nano silver-based dressing

Conditions studied

• Diabetes Mellitus — all drugs for Diabetes Mellitus →

Sponsor

Magda Bayoumi

Who can join

Adults 35 to 55, any sex, with Diabetes Mellitus. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background: The wound dressings perform a crucial role in the cutaneous wounds' management due to their ability to protect wounds and promote dermal and epidermal tissue regeneration. Objective: the aim of the present study to evaluate the effectiveness of using hydrogel/nano silver-based dressing vs. traditional dressing on diabetic foot wound healing.

Approach: Sixty patients with type-2 diabetes hospitalized for diabetic foot wound treatment were recruited from selected Surgical departments at Kasr Al-Aini university hospital.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties.
   Chen Y, Wang X, Tao S, Wang Q, et al · · 2023 · cited 160× · PMID 37608335 · DOI 10.1186/s40779-023-00473-9
2. Current Overview of Metal Nanoparticles' Synthesis, Characterization, and Biomedical Applications, with a Focus on Silver and Gold Nanoparticles.
   Burlec AF, Corciova A, Boev M, Batir-Marin D, et al · · 2023 · cited 93× · PMID 37895881 · DOI 10.3390/ph16101410
3. Nanocomposite hydrogels for biomedical applications.
   Huang S, Hong X, Zhao M, Liu N, et al · · 2022 · cited 79× · PMID 36176618 · DOI 10.1002/btm2.10315
4. Biomedical Applications of Plant Extract-Synthesized Silver Nanoparticles.
   Simon S, Sibuyi NRS, Fadaka AO, Meyer S, et al · · 2022 · cited 46× · PMID 36359308 · DOI 10.3390/biomedicines10112792
5. Plant Extract-Synthesized Silver Nanoparticles for Application in Dental Therapy.
   Ahmed O, Sibuyi NRS, Fadaka AO, Madiehe MA, et al · · 2022 · cited 41× · PMID 35214112 · DOI 10.3390/pharmaceutics14020380
6. Recent Advances in Silver Nanoparticles Containing Nanofibers for Chronic Wound Management.
   Sabarees G, Velmurugan V, Tamilarasi GP, Alagarsamy V, et al · · 2022 · cited 32× · PMID 36235942 · DOI 10.3390/polym14193994
7. Nanobiotechnology: Applications in Chronic Wound Healing.
   Jiang T, Li Q, Qiu J, Chen J, et al · · 2022 · cited 32× · PMID 35898438 · DOI 10.2147/ijn.s372211
8. Functional Thermoresponsive Hydrogel Molecule to Material Design for Biomedical Applications.
   Pardeshi S, Damiri F, Zehravi M, Joshi R, et al · · 2022 · cited 29× · PMID 35956641 · DOI 10.3390/polym14153126