NCT04831073: ERTAAD

European Registry of Type A Aortic Dissection

Completed Last updated 11 December 2024

What this trial tests

trial testing Surgery on the ascending aorta with or without repair of the aortic root and/or aortic arch in Type A Aortic Dissection in 3,902 participants. Completed in 6 December 2024.

Timeline

28 February 2023

Primary endpoint
6 December 2024

6 December 2024

Quick facts

Lead sponsor	Helsinki University Central Hospital
Status	Completed
Study type	OBSERVATIONAL
Enrollment	3,902
Start date	28 February 2023
Primary completion	6 December 2024
Estimated completion	6 December 2024
Sites	20 locations across France, Italy, Finland, Belgium, United Kingdom, Germany, Spain, Czechia

Drugs / interventions tested

• Surgery on the ascending aorta with or without repair of the aortic root and/or aortic arch

Conditions studied

• Type A Aortic Dissection — all drugs for Type A Aortic Dissection →

Sponsor

Helsinki University Central Hospital

Who can join

18 and older, any sex, with Type A Aortic Dissection. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Acute Stanford type A aortic dissection (TAAD) is a life-threatening condition. Surgery is usually performed as a salvage procedure and is associated with significant postoperative early mortality and morbidity. Understanding the patient's conditions and treatment strategies which are associated with these adverse events is essential for an appropriate management of acute TAAD.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. European registry of type A aortic dissection (ERTAAD) - rationale, design and definition criteria.
   Biancari F, Mariscalco G, Yusuff H, Tsang G, et al · · 2021 · cited 28× · PMID 34112230 · DOI 10.1186/s13019-021-01536-5
2. Interinstitutional analysis of the outcome after surgery for type A aortic dissection.
   Biancari F, Dell'Aquila AM, Gatti G, Perrotti A, et al · · 2023 · cited 7× · PMID 36826589 · DOI 10.1007/s00068-023-02248-2
3. Role of gender in short- and long-term outcomes after surgery for type A aortic dissection: analysis of a multicentre European registry.
   Onorati F, Francica A, Demal T, Nappi F, et al · · 2024 · cited 5× · PMID 38924518 · DOI 10.1093/ejcts/ezae242
4. Aortic arch surgery for DeBakey type 1 aortic dissection in patients aged 60 years or younger.
   Biancari F, Lega JR, Mariscalco G, Peterss S, et al · · 2024 · cited 5× · PMID 38768283 · DOI 10.1093/bjsopen/zrae047
5. Baseline risk factors of in-hospital mortality after surgery for acute type A aortic dissection: an ERTAAD study.
   Biancari F, Demal T, Nappi F, Onorati F, et al · · 2023 · cited 5× · PMID 38288052 · DOI 10.3389/fcvm.2023.1307935
6. Outcome after day- and nighttime surgery for acute type A aortic dissection.
   Demal TJ, Knochenhauer T, Weimann J, Juvonen T, et al · · 2025 · cited 4× · PMID 40569847 · DOI 10.1093/ejcts/ezaf192
7. Direct Aortic Versus Supra-Aortic Arterial Cannulation During Surgery for Acute Type A Aortic Dissection.
   Juvonen T, Jormalainen M, Mustonen C, Demal T, et al · · 2023 · cited 4× · PMID 37432422 · DOI 10.1007/s00268-023-07116-z
8. Extent of surgical repair and outcomes after surgery for type A aortic dissection.
   Biancari F, Fileccia D, Ferrante L, Mäkikallio T, et al · · 2025 · cited 3× · PMID 40071739 · DOI 10.1093/bjsopen/zraf003